PRACTICAL ONCOLOGY JOURNAL ›› 2009, Vol. 23 ›› Issue (2): 126-129.doi: 10.3969/j.issn.1002-3070.2009.02.006

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A clinical study of combination of radiotherapy and IP regimen in the treatment of patients with local advanced esophageal cancer

GAO Fei1, JIA Lin1, DU Huizhang2, WANG Yun1, KUANG Xiaohong1, HAN Jianjun1   

  1. 1.The Tthird Hospital of Mianyang, Sichuan, 621000;
    2.The Tumor Hospital of Yan Ting, Sichuan, 621600
  • Received:2009-01-12 Online:2009-04-20 Published:2012-02-21

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Abstract: Objective To study the clinical efficacy and toxicity of combination of the radiotherapy and IP regimen for patients with local advanced esophageal cancer.Methods 68 cases of local advanced esophageal cancer were randomized into two groups, simple irradiation group(control group, n=33)receiving conventional radiotherapy to a total of 60Gy, combined group(research group, n=35)which received the same radiotherapy as simple irradiation group plus chemotherapy with IP regimen, patients in research group were treated with infusion of Irinotecan 65mg/m2 and DDP 30mg/m2 on day 1, 8.21 days was a cycle and 4 cycles were given.Results The remission rate, one and two year disease-free survival rate in research group were significant higher than that in control group.But the incidence of nausea, vomiting, myelosuppression and diarrhea was higher in research group.Conclusion The efficacy of concomitant radiotherapy and IP regimen for local advanced esophageal cancer is obvious and it can improve the survival rate of patients, which is worthy of clinical application.

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