Abstract: To study the relationship between proliferating cell and lymphatic vessel and angiogenesis in gastric cancer. Methods We observed the central cancer tissues and the peritumoral tissues of 67 patients with gastric carcinoma by immunohistochemistry.Using D2-40、VEGFR-C and VEGFR-3 detected the micro-lymphatic density(MLD), microvessel density(MVD)were evaluated by immunohistochemistry with CD31 and CD34 antibodies.The proliferation of the cells was labeled by Ki-67.Results There is a few atresic streak lympgatic vessel in the central cancer tissues, but in the peritumoral tissues lymphatic increased and dilated, it appears adenoid structure.To compare with micro-lymphatic density in the central cancer tissues(33.6±13.9)and the peritumoral tissues(61.7±21.4), the result is significantly different(P＜ 0.01).The differences in the distribution and amount of microvessel are similar to lympgatic vessel.There is a few focal distribution Ki-67 positive carcinoma, but in the peritumoral tissues the situation is reverse especially in one low-power size(×10).Compared with Ki-67 positive cells in different tumor region, in the central cancer tissues Ki-67 positive cells decreased markedly(P ＜ 0.01).Conclusion There exist neonatal lymphatic vessels、blood vessel and many Ki-67 positive carcinoma in gastric cancer.All of them distribute anterior border of carcinoma tissues, especially in one low-power size(×10).The MLD、MVD and Ki-67 positive carcinoma might be an important index for the prognosis of gastric carcinoma.The more lymphatic microvessel、microvessel and Ki-67 positive carcinoma in the peritumoral tissues, the poorer prognosis, vice versa, good prognosis.