PRACTICAL ONCOLOGY JOURNAL ›› 2011, Vol. 25 ›› Issue (4): 315-318.doi: 10.3969/j.issn.1002-3070.2011.04.004

Previous Articles     Next Articles

The meta-analysis between p53 alteration and smoking,alcohol consumption in esophageal cancer among Chinese population

ZHANG Yuxue1,WU Haiyan2,LI Huiyan3   

  1. 1.Public Health School,Harbin Medical University,Harbin 150081;
    2.ShenZhen Entry-Exit Inspection And Quarantine Bureau;
    3.ZheJiang Province PingYang County Center For Disease Control And Prevention
  • Received:2011-06-01 Online:2011-04-25 Published:2012-02-21

PDF (PC)

67

Abstract: Objective To explore the association between smoking,alcohol consumption and p53 alteration in esophageal cancer among Chinese population.Method A systematic search was performed using the Medline and CNKI databases,and the eligible literatures were systematic reviewed.Results Fourteen studies were eligible for analysis,involving 2108 esophageal cancer cases and 1142(54.2%)p53 alteration cases.Among Chinese population,the pooled OR for the association between smoking,alcohol drinking and p53 alteration in esophageal cancer were 1.61(95% CI:1.09-2.38;P=0.003)and 1.91(95% CI:1.44-2.53;P＜0.001),respectively.Conclusion The findings of this meta-analysis indicated that there were significant associations between smoking,alcohol consumption and p53 alteration in esophageal cancer among Chinese population.

CLC Number: