Abstract: Small-cell lung cancer(SCLC)accounts for 15%~20% of all lung cancer worldwide.Many medical scientists pay more attention to it,due to its pathophysiology feature and high malignancy.The c-kit protein is a member of the type III receptor tyrosine kinase family.It promotes some normal cells differentiation,proliferation,and maintain cell function.Recent studies found that the expression and mutation of c-kit exist in small cell lung cancer samples.People presume that the mechanism of SCLC is relation to expression and mutation of c-kit.This article demonstrate the progression of c-kit receptor in SCLC.