Abstract: Biliary tract malignant tumors are aggressive,high malignant and have a poor prognosis.Early radical resection is currently the preferred treatment method and the only possible long-term survival method.However,most patients are already at an advanced stage when they are diagnosed,and only about 20% of the patients have the chance of surgery.Not only that,even if radical surgery is performed,the recurrence rate is still extremely high.In order to reduce the postoperative recurrence rate,people have been committed to exploring adjuvant treatment strategies for many years,including radiotherapy,chemotherapy and combination of radiotherapy and chemotherapy.However,most of the data come from phase II clinical trials and retrospective studies,and there is a lack of high-quality data to confirm the effects of adjuvant therapy.In recent years,with the release of several large randomized clinical trials and the development of precision treatments,more and more studies have focused on this field,and the results are promising.This review summarizes and analyzes recent research data in the field of adjuvant treatment of biliary malignant tumors,and discusses future research directions.

Key words: Biliary malignant tumors, Adjuvant therapy, Radiotherapy and chemotherapy, Targeted therapy, Immunotherapy