肌少症与晚期非小细胞肺癌临床病理特征及预后的相关性分析

doi:10.11904/j.issn.1002-3070.2022.03.004

Abstract

Abstract: Objective The objective of this study was to determine the clinicopathological characteristics of advanced non-small cell lung cancer patients with sarcopenia,and to evaluate the effect of sarcopenia on progression-free survival(PFS)and overall survival(OS)in advanced non-small cell lung cancer patients. Methods A total of 112 patients with stage IIIb-IV non-small cell lung cancer who were treated in our hospital from June 2017 to December 2019 were selected,and the patients were divided into the sarcopenia group(64 cases)and the non-sarcopenia group(48 cases).All patients were followed up by telephone or outpatient service.PFS and OS between the two groups were compared.Cox regression was used to analyze the prognostic risk factors of advanced non-small cell lung cancer. Results The survival rates of PFS and OS in the group with sarcopenia were lower than those in the group without sarcopenia(P＜0.05).Multivariate Cox hazard proportional regression analysis showed that sarcopenia and T stage were independent risk factors for PFS in patients with advanced non-small cell lung cancer(P＜0.05);sarcopenia and lymph node metastasis were independent risk factors for OS in patients with advanced non-small cell lung cancer(P＜0.05). Conclusion The PFS and OS of advanced non-small cell lung cancer patients with sarcopenia are lower than those of non-sarcopenic patients,sarcopenia may be used as a prognostic indicator for advanced non-small cell lung cancer patients.

Key words: Sarcopenia, Advanced non-small cell lung cancer, Pathological features, Risk factors, Prognosis

CLC Number:

R734.2

ZHANG Hao, YANG Xinguan, HE Yong. Analysis of the correlation between sarcopenia and the clinicopathological characteristics and prognosis of advanced NSCLC[J]. Journal of Practical Oncology, 2022, 36(3): 214-219.

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URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2022.03.004

http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2022/V36/I3/214

References

1 赫捷,李霓,陈万青,等.中国肺癌筛查与早诊早治指南(2021,北京)[J].中华肿瘤杂志,2021,43(3):243-268.
2 宁晔,谢冬,佘云浪,等.2020版NCCN肺癌筛查指南解读[J].中国胸心血管外科临床杂志,2020,27(3):251-254.
3 董晓平,张雪,郭冬利,等.肺鳞状细胞癌预后相关影响因素研究进展[J].实用肿瘤学杂志,2021,35(4):380-385.
4 方志红,李天苗,许荣忠,等.246例非小细胞肺癌的预后影响因素分析[J].现代肿瘤医学,2017,25(8):1234-1236.
5 Marasco G,Serenari M,Renzulli M,et al.Clinical impact of sarcopenia assessment in patients with hepatocellular carcinoma undergoing treatments[J].J Gastroenterol,2020,55(10):927-943.
6 Schaffler-Schaden D,Mittermair C,Birsak T,et al.Skeletal muscle index is an independent predictor of early recurrence in non-obese colon cancer patients[J].Langenbecks Arch Surg,2020,405(4):469-477.
7 Fearon K,Strasser F,Anker SD,et al.Definition and classification of cancer cachexia:an international consensus[J].Lancet Oncol,2011,12(5):489-495.
8 刘娟,丁清清,周白瑜,等.中国老年人肌少症诊疗专家共识(2021)[J].中华老年医学杂志,2021,40(8):943-952.
9 Cawthon PM.Recent progress in sarcopenia research:a focus on operationalizing a definition of sarcopenia[J].Curr Osteoporos Rep,2018,16(6):730-737.
10 李周华,季爽,胡先纬,等.肺癌患者并发肌肉减少症的危险因素分析及其与临床预后的相关性探讨[J].中国全科医学,2021,24(26):3310-3315.
11 Suzuki Y,Okamoto T,Fujishita T,et al.Clinical implications of sarcopenia in patients undergoing complete resection for early non-small cell lung cancer[J].Lung Cancer,2016,101:92-97.
12 Rossi S,Di Noia V,Tonetti L,et al.Does sarcopenia affect outcome in patients with non-small-cell lung cancer harboring EGFR mutations?[J].Future Oncol,2018,14(10):919-926.
13 Shiroyama T,Nagatomo I,Koyama S,et al.Impact of sarcopenia in patients with advanced non-small cell lung cancer treated with PD-1 inhibitors:a preliminary retrospective study[J].Sci Rep,2019,9(1):2447.
14 任姗姗,李冠臻,汪明芳,等.高龄老年人肌少症与膳食摄入的相关性研究[J].中华老年医学杂志,2021,40(2):212-215.
15 Beaudart C,Dawson A,Shaw SC,et al.Nutrition and physical activity in the prevention and treatment of sarcopenia:systematic review[J].Osteoporos Int,2017,28(6):1817-1833.
16 Cereda E,Turri A,Klersy C,et al.Whey protein isolate supplementation improves body composition,muscle strength,and treatment tolerance in malnourished advanced cancer patients undergoing chemotherapy[J].Cancer Med,2019,8(16):6923-6932.
17 唐微,闫翔,范萍,等.膳食营养干预联合抗阻力训练治疗老年男性肌少症患者的临床效果分析[J].现代生物医学进展,2020,20(14):2698-2701.
18 樊菡,王莉,李潇.不同分期老年肌少症患者睾酮、雌二醇、IL-6水平的相关性[J].中华骨质疏松和骨矿盐疾病杂志,2021,14(1):35-40.

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Analysis of the correlation between sarcopenia and the clinicopathological characteristics and prognosis of advanced NSCLC

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