Abstract: Objective To analyze the long-term trend of mortality and years of life lost(YLL)of stomach cancer in Nanjing from 2007 to 2019. Methods From January 1,2007 to December 31,2019,the date of stomach cancer deaths was collected from the Nanjing Surveillance System for all causes of death.The crude and age-standardized mortality rate of stomach cancer was calculated according to Chinese standard population in 2000.The Joinpoint regression was used to calculate the average annual percentage change(AAPC)to indicate the trend of mortality and YLL rates of stomach cancer. Results From 2007 to 2019,there were 32 187 deaths of stomach cancer in Nanjing,22 296 in male and 9 891 in female,the crude rates of male were higher than female(52.64/10⁵ vs. 23.61/10⁵,u=2.281,P＜0.05),10 591 in urban areas and 21 596 in rural areas,the crude rates of urban areas were lower than rural areas(26.02/10⁵ vs. 49.56/10⁵,u=55.257,P＜0.05).The mortality rates of stomach cancer increased from the age of 40 years and peaked in age group of 80-years in males,peaked in age group of 85-years in females.From 2007 to 2019,the crude mortality and age-standardized mortality were decreased with year(AAPC,crude mortality:-2.65%,age-standardized mortality:-7.69%,P＜0.05).The total YLL numbers were 681,511 person-years and the rates were 8.09 person-years per thousand.From 2007 to 2019 was,YLL rates were decreased with year(AAPC was-3.86%,P＜0.05),and increased with age(the AAPC was 52.43%,P＜0.05),and the rates of males increased faster than those of females(AAPC,males:54.90%,females:49.70%,P＜0.05). Conclusion The mortality of stomach cancer varied with sex,age and areas(urban area and rural area).The present analysis provides the character of stomach cancer in Nanjing,which can help optimize the screening and prevention strategies of stomach cancer to improve life quality and reduce the disease burden.

Key words: Stomach cancer, Mortality, Years of life lost, Trend