Abstract: Objective The Objective of this study was to analyze the disease burden of malignant tumors among the people aged 30 and above in Sichuan province in 2010 and 2020,and provide a reference and basis for the formulation of prevention and control decisions for malignant tumors. Methods The data of mortality from malignant tumors and the total population in Sichuan province were collected.The mortality,disability-adjusted life year(DALY),years of life lost(YLL),and years lived with disability(YLD)were calculated by age group,gender,and major type to evaluate the disease burden of malignant tumors. Results The mortality of malignant tumors in the population aged 30 and above in Sichuan province in 2020 was 259.26/100,000,an increase of 34.33% compared to 2010.The standardized mortality was 187.08 per 100,000,an increase of 7.52% compared to 2010.The DALY rate of malignant tumors in the population aged 30 and above in Sichuan province in 2020 was 21.11/1,000,of which the YLL rate accounted for 97.82% and the YLD rate accounted for 2.18%.The YLL rate was higher than the YLD rate(P＜0.001).The DALY rate in males was higher than that in females(P＜0.001).The standardized DALY rate of malignant tumors in the population aged 30 and above in 2020 increased by 14.58% compared to 2010,with the fastest growth rates observed in the age groups of 30-44 and 60-69,with growth rates of 30.96% and 25.74%,respectively.In 2020,the top five standardized DALY rates of malignant tumors among the people aged 30 and above were lung cancer,liver cancer,esophageal cancer,colorectal cancer,and gastric cancer.Among them,lung cancer and colorectal cancer increased by 33.45% and 46.56%,respectively,compared to 2010,while gastric cancer decreased by 22.81%,the esophageal cancer in women decreased by 18.51% and there was little change in men.Liver cancer decreased by 8.15% in females and increased by 3.45% in males.In 2020,the standardized DALY rate of female breast cancer and cervical cancer increased by 37.14% and 94.52%,respectively,compared with 2010. Conclusion By 2020,the disease burden of malignant tumors among people aged 30 and above in Sichuan province is still heavy,and early death is the main source of their disease burden.The key prevention and control diseases are lung cancer,colorectal cancer,breast cancer,and cervical cancer.

Key words: Sichuan province, Malignant tumors, Disease burden, Mortality, Disability- adjusted life year