Principles and methods of sequence stratigraphy for outcrops, drilling cores and well logs have been used for reconstructing the Paleogene sequence stratigraphic framework in the Tarim Basin. Extensive investigations of the outcrop, borehole and well log data revealed that a total of 6 third order sequence boundaries and 5 thirdorder sequences were developed in the Paleogene in the Tarim Basin. Three sequences, namely S1, S2 and S3, were developed from Paleocene to Early Eocene (the deposition period of Kumugeliemu Group and its equivalents). On the whole, S1 is equivalent to the basal conglomerate member, gypsum and gypseous mudstone member to dolostone member of the Kumugeliemu Group in the Kuqa Depression, and is equivalent to the Tuyiluoke Formation in the southwestern Tarim area. S2 and S3 correspond to the two gypsumcontaining members developed in the upper part of the Kumugeliemu Group in the Kuqa Depression, respectively. They are equivalent to the two gypsum intervals in the Aertashi Formationthe Qimugen Formation and the Kalataer Formationthe Wulagen Formation in the southwestern Tarim Depression. Two sequences, S4 and S5 were developed from Late Eocene to Oligocene (the deposition period of the Suweiyi Formation and its equivalents). S4 is equivalent to the Suweiyi Formation in the Kuqa Depression and the main part of the the Bashibulake Formation in the southwestern Tarim Depression, and S5 is only locally developed at the top of the Suweiyi Formation in a few boreholes and it is characterized by the fan delta sandy conglomerates. Within these sequences, the lowstand systems tracts are represented by the conglomerates and sandstones of fan delta distributary channel and braided channel as well as the thickbedded gypsum and gypseous rocks of saline lagoon and evaporate platform. The transgressive systems tracts are dominated by coastalshallow lacustrine mudstones and siltstones, and the highstand systems tracts are mainly composed of the carbonate rocks and mudstoneabundant successions.