Caveolin-1的表达与EGFR突变在NSCLC中的相关性及其临床意义的研究

doi:10.11904/j.issn.1002-3070.2014.06.004

实用肿瘤学杂志 ›› 2014, Vol. 28 ›› Issue (6): 498-502.doi: 10.11904/j.issn.1002-3070.2014.06.004

Caveolin-1的表达与EGFR突变在NSCLC中的相关性及其临床意义的研究

徐睿瑞, 温荔媛, 孙国强, 孟庆威, 孙立春, 蔡莉

哈尔滨医科大学附属肿瘤医院内四科(哈尔滨 150081)

收稿日期:2014-07-20 出版日期:2014-12-28 发布日期:2015-01-08
通讯作者: 孙立春,E-mail:sunlichun114@126.com
作者简介:徐睿瑞,女,(1985-),硕士研究生,从事乳腺癌及肺癌的诊断与治疗的研究
基金资助:
黑龙江省教育厅科学技术研究项目(12541457);黑龙江省自然科学基金项目(H201447);国家自然科学基金项目(30772540,81172214)

Research on the expression of Caveolin-1 with EGFR mutations in non-small cell lung cancer tissues and its clinical significance

XU Ruirui,WEN Liyuan,SUN Guoqiang,MENG Qingwei,SUN Lichun,CAI Li

Department of Internal Medical,The Affiliated Tumor Hospital of Harbin Medical University,Harbin 150081,China

Received:2014-07-20 Online:2014-12-28 Published:2015-01-08

摘要/Abstract

摘要：

目的研究Caveolin-1在非小细胞肺癌(NSCLC)中的表达,探讨Caveolin-1的表达与肺癌表皮生长因子受体(EGFR)突变的关系。方法运用免疫组织化学法检测哈尔滨医科大学附属肿瘤医院40例NSCLC组织中Caveolin-1表达,同时应用ARMS-qPCR方法检测EGFR突变情况,并结合患者的临床病理特征和相关性进行分析。结果 Caveolin-1在NSCLC组织中阳性表达率显著低于正常肺组织,NSCLC组织中Caveolin-1表达与组织学类型相关,同时与EGFR突变呈负相关,差异有统计学意义(P＜0.05)。结论 Caveolin-1表达与EGFR突变在NSCLC中呈负相关,与组织学类型密切相关,可能成为诊断和判定NSCLC临床预后的重要分子指标。

关键词: Caveolin-1, EGFR突变, 非小细胞肺癌, 免疫组化

Abstract:

Objective This study aims to examine expression of Caveolin-1 in non smoking cell lung cancer(NSCLC)and to discusses the relationship between expression of Caveolin-1 and the Epidermal growth factor receptor mutations.Methods Immunohistochemical staining was used to determine the Caveolin-1 expression and ARMS-qPCR was used to measure EGFR mutations in 40 cases of lung cancer tissue.The clinical pathological characteristics and correlations in patients were analyzed.Results The expression of Caveolin-1 in human lung cancer was significantly lower than that in normal lung tissue,and negatively correlated with EGFR mutations,which was statistically significant.Conclusion Caveolin-1 expression is negatively correlated with EGFR mutations in non-small cell lung cancer and related to the histologic type.Caveolin-1 may be a molecular target for diagnosis and judgment of NSCLC.

Key words: Caveolin-1, EGFR mutation, Non-small cell lung carcinoma, Immunohistochemical

中图分类号:

R734.2

徐睿瑞, 温荔媛, 孙国强, 孟庆威, 孙立春, 蔡莉. Caveolin-1的表达与EGFR突变在NSCLC中的相关性及其临床意义的研究[J]. 实用肿瘤学杂志, 2014, 28(6): 498-502.

XU Ruirui,WEN Liyuan,SUN Guoqiang,MENG Qingwei,SUN Lichun,CAI Li. Research on the expression of Caveolin-1 with EGFR mutations in non-small cell lung cancer tissues and its clinical significance[J]. PRACTICAL ONCOLOGY JOURNAL, 2014, 28(6): 498-502.

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Caveolin-1的表达与EGFR突变在NSCLC中的相关性及其临床意义的研究

Research on the expression of Caveolin-1 with EGFR mutations in non-small cell lung cancer tissues and its clinical significance

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