CYP24A1基因多态性与大肠癌发生及预后的关系

doi:10.11904/j.issn.1002-3070.2015.04.001

实用肿瘤学杂志 ›› 2015, Vol. 29 ›› Issue (4): 289-293.doi: 10.11904/j.issn.1002-3070.2015.04.001

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CYP24A1基因多态性与大肠癌发生及预后的关系

宫晨¹ ,周军德² ,迟强² ,崔滨滨³ ,赵亚双¹ ,王帆¹

1.哈尔滨医科大学公共卫生学院流行病学教研室(哈尔滨 150086);
2.哈尔滨医科大学附属第二医院结直肠外科;
3.哈尔滨医科大学附属肿瘤医院腹外科

收稿日期:2015-03-03 出版日期:2015-08-27 发布日期:2015-08-27
通讯作者: 赵亚双 E-mail:zhao＿yashuang@263.net
作者简介:宫晨,女,(1988-),硕士研究生,从事大肠癌的分子流行病学研究
基金资助:
中国博士后科学基金(20100481026);国家教育部博士项目基金(20122307120005)

Associations between CYP24A1 gene polymorphisms and the risk and prognosis of colorectal cancer

GONG Chen¹,ZHOU Junde²,CHI Qiang²,CUI Binbin³,ZHAO Yashuang¹,WANG Fan¹

1.Department of Epidemiology,Public Health College,Harbin Medical University,Harbin 150086,China;
2.Department of Colorectal Surgery,The Second Affiliated Hospital of Harbin Medical University;
3.Department of Abdominal Surgery,The Affiliated Tumor Hospital of Harbin Medical University

Received:2015-03-03 Online:2015-08-27 Published:2015-08-27

摘要/Abstract

摘要：

目的探讨CYP24A1基因多态位点对大肠癌发生和预后的影响。方法采用病例-对照研究方法对528例大肠癌患者和605例对照进行维生素D代谢相关基因CYP24A1的Rs4809957和Rs2762934多态位点与大肠癌发病关系的分析,并探讨多态位点与饮食因素的联合作用和交互作用与大肠癌发生的关系;随访317例大肠癌患者,探讨多态位点与大肠癌预后的关系。结果 Rs4809957和Rs2762934多态位点与饮食因素的联合作用与大肠癌的发病有关。对于Rs4809957多态位点,与GG/GA基因型相比,携带AA基因型的大肠癌患者、结肠癌患者和直肠癌患者的预后均较差(Log-rank检验分别为P=0.01,P=0.01,P=0.02);与野生型GG相比,AA基因型可导致大肠癌患者(HR=2.35,95% CI:1.28~4.30)、结肠癌患者(HR=2.37,95% CI:1.09~5.14)、直肠癌患者(HR=2.11,95%CI:1.11~4.01)预后不良。结论 CYP24A1基因Rs4809957和Rs2762934多态位点与饮食因素的联合作用与大肠癌的易感性有关,且Rs4809957多态位点可能会影响大肠癌患者的预后。

关键词: 大肠癌, CYP24A1, 单核苷酸多态性, 风险, 预后

Abstract:

Objective To explore the associations between polymorphisms in CYP24A1 gene and the risk and prognosis of colorectal cancer (CRC).Methods A case-control study consisting of 528 CRC patients and 605 cancer free controls and a follow up study with 317 cases were conducted to explore the associations between two polymorphisms in CYP24A1 and the risk and prognosis of CRC,as well as the combinations and interactions of polymorphisms with dietary factors on CRC risk.Results Although there was no association between polymorphisms in CYP24A1 and the risk of CRC,significant combinative effects between polymorphisms and dietary factors on CRC risk were observed.For Rs4809957 polymorphism,the prognosis of AA genotype carriers was worse than GG/GA carriers in CRC,colon cancer and rectal cancer(Log-rank test P=0.01,P=0.01,P=0.02,respectively).Compared with GG genotype,AA genotype carriers of Rs4809957 polymorphism had worse prognosis in CRC(HR = 2.35,95% CI = 1.28~4.30),colon caner(HR = 2.37,95% CI =1.09~5.14)and rectal cancer(HR = 2.11,95% CI = 1.11~4.01).Conclusion The combinations of the polymorphisms in CYP24A1 gene with dietary factors are associated with the susceptibility of CRC,and Rs4809957 polymorphism may lead to a worse prognosis of CRC.

Key words: Colorectal cancer, CYP24A1, Polymorphisms, Risk, Prognosis

中图分类号:

R735

宫晨,周军德,迟强,崔滨滨,赵亚双,王帆. CYP24A1基因多态性与大肠癌发生及预后的关系[J]. 实用肿瘤学杂志, 2015, 29(4): 289-293.

GONG Chen,ZHOU Junde,CHI Qiang,CUI Binbin,ZHAO Yashuang,WANG Fan. Associations between CYP24A1 gene polymorphisms and the risk and prognosis of colorectal cancer[J]. PRACTICAL ONCOLOGY JOURNAL, 2015, 29(4): 289-293.

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CYP24A1基因多态性与大肠癌发生及预后的关系

Associations between CYP24A1 gene polymorphisms and the risk and prognosis of colorectal cancer

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