脑胶质瘤中CDK4和β-Catenin表达及临床意义的研究

doi:10.11904/j.issn.1002-3070.2015.05.005

实用肿瘤学杂志 ›› 2015, Vol. 29 ›› Issue (5): 404-408.doi: 10.11904/j.issn.1002-3070.2015.05.005

脑胶质瘤中CDK4和β-Catenin表达及临床意义的研究

董天华¹, 沈欣², 梁亚男³, 刘宇³, 佟丹丹³

1.哈尔滨红十字中心医院神经外科(哈尔滨 150081);
2.哈尔滨红十字中心医院急诊科;
3.哈尔滨医科大学病理科

收稿日期:2015-06-16 出版日期:2015-10-28 发布日期:2015-10-30
通讯作者: 佟丹丹,E-mail:tongdd1977@163.com
作者简介:董天华,男,(1979-),本科,主治医师,从事神经外科方向的研究

The research on CDK4 and β-Catenin expression and clinic significance in glioma

DONG Tianhua¹, SHEN Xin², LIANG Yanan³, LIU Yu³, TONG Dandan³

1.Department of Neurosurgery,Harbin Red Cross Central Hospital,Harbin 150081,China;
2.Department of Emergency,Harbin Red Cross Central Hospital;
3.Department of Pathology,Harbin Medical University

Received:2015-06-16 Online:2015-10-28 Published:2015-10-30

摘要/Abstract

摘要： 目的研究脑胶质瘤中CDK4和β-Catenin的表达情况及相关性。方法采用免疫组织化学法检测45例脑胶质瘤组织和8例癌旁正常组织中CDK4和β-Catenin的表达,并将其按WHO 2000年神经系统肿瘤病理学分级标准进行分类分级,进行统计学分析。结果 45例脑胶质瘤组织中CDK4和β-Catenin阳性表达率分别为73.3%和77.8%,与癌旁正常组织之间的差异具有统计学意义(P＜0.05)。CDK4和β-Catenin的表达均与WHO分级和组织学分型相关(P＜0.05),与患者性别、年龄之间差异无统计学意义(P＞0.05)。CDK4和β-Catenin的表达呈正相关(r=0.52,P＜0.01),二者表达均阳性患者恶性程度高。结论脑胶质瘤中CDK4和β-Catenin的表达增高可能与胶质瘤的恶性变和恶性胶质瘤的发生有关,二者相结合有望成为胶质瘤恶性评估的重要指标。

关键词: 脑胶质瘤, CDK4, β-Catenin

Abstract: Objective To study the expression of CDK4 and β-Catenin and their relevance in glioma.Methods We used immunohistochemistry to detect the expression of CDK4 and β-Catenin in forty-five glioma tissues and eight normal tissues.According to the classification standard of WHO in 2000 classify and grade the tissues.Results There were significant differences of CDK4 and β-Catenin expressions between normal tissues and glioma tissues(P＜0.01).The expression of CDK4 and β-Catenin had positive correlation with the pathological grades of glioma and histological type and increased(P＜0.05).Furthermore,the expression of CDK4 was positively correlated with the expression of β-Catenin in glioma(r=0.52,P＜0.01).Conclusion The increased expression of CDK4 and β-Catenin may have correlation with malignant change of glioma and occurance of glioblastoma,and their combination is expected to become an important indicator in assessing malignant glioma.

Key words: Glioma, CDK4, β-Catenin

中图分类号:

R739.41

董天华, 沈欣, 梁亚男, 刘宇, 佟丹丹. 脑胶质瘤中CDK4和β-Catenin表达及临床意义的研究[J]. 实用肿瘤学杂志, 2015, 29(5): 404-408.

DONG Tianhua, SHEN Xin, LIANG Yanan, LIU Yu, TONG Dandan. The research on CDK4 and β-Catenin expression and clinic significance in glioma[J]. PRACTICAL ONCOLOGY JOURNAL, 2015, 29(5): 404-408.

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脑胶质瘤中CDK4和β-Catenin表达及临床意义的研究

The research on CDK4 and β-Catenin expression and clinic significance in glioma

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