TACE后残余肝癌细胞β-catenin和p28GANK的表达及意义的研究

doi:10.11904/j.issn.1002-3070.2016.05.009

实用肿瘤学杂志 ›› 2016, Vol. 30 ›› Issue (5): 430-435.doi: 10.11904/j.issn.1002-3070.2016.05.009

TACE后残余肝癌细胞β-catenin和p28GANK的表达及意义的研究

李世杰¹, 杨奕¹, 田玉龙¹, 侯继野², 刘瑞宝¹

1.哈尔滨医科大学附属肿瘤医院介入科(哈尔滨 150081);
2.齐齐哈尔市第一医院介入科

收稿日期:2016-07-28 出版日期:2016-10-28 发布日期:2016-11-02
通讯作者: 刘瑞宝,E-mail:ruibaoliu@hotmail.com
作者简介:李世杰,男,(1985-),硕士,住院医师,从事腹部肿瘤的影像诊断与介入治疗的研究

The expression and significance of β-catenin and p28GANK in residual hepatocellular carcinoma cells after transcatheter arterial chemoembolization

LI Shijie¹, YANG Yi¹, TIAN Yulong¹, HOU Jiye², LIU Ruibao¹

1.Department of Interventional Radiology,The Affiliated Tumor Hospital of Harbin Medical University,Harbin 150081,China;
2.Department of Interventional Radiology,The First Hospital of Qiqihaer City

Received:2016-07-28 Online:2016-10-28 Published:2016-11-02

摘要/Abstract

摘要： 目的探讨经导管动脉化疗栓塞术(Transcatheter arterial chemoembolization,TACE)后残余肝癌细胞β-连环蛋白(β-catenin)和p28GANK的表达及意义。方法收集TACE后手术切除的肝细胞癌组织标本45例(TACE组)和未经任何治疗直接手术切除的肝细胞癌组织标本30例(单纯手术组)。采用免疫组化SP法检测残余肝细胞癌中β-catenin、p28GANK的表达水平。结果 TACE组组织标本β-catenin和p28GANK的表达阳性率分别为77.78%和75.56%,单纯手术组肝癌组织标本β-catenin和p28GANK的表达阳性率分别为46.67%和53.33%,两组差异具有统计学意义(P＜0.05)。TACE组残余肝细胞癌中β-catenin和p28GANK的阳性表达存在相关性(Φ=0.318,P=0.033)。TACE组β-catenin和p28GANK的高表达与患者门静脉癌栓形成和肿瘤远处转移有关(P＜0.05)。结论原发性肝癌TACE后残余肝细胞癌β-catenin和p28GANK的表达明显升高,β-catenin和p28GANK的高表达与患者存在门静脉癌栓和肿瘤的远处转移有关。β-catenin和p28GANK的高表达可能是TACE后肿瘤侵袭、转移的原因之一。

关键词: 肝细胞癌, 经导管动脉化疗栓塞术, β-catenin, p28GANK

Abstract: Objective To investigate the expression and significance of β-catenin and p28GANK in residual hepatocellular carcinoma(HCC)cells after transcatheter arterial chemoembolization(TACE).Methods We collected forty-five cases of surgical specimens of hepatocellular carcinoma after TACE(TACE group)and thirty cases of surgery without any treatment(pure surgery group).The expression of β-catenin and p28GANK were detected by using immunohistochemical SP method and compared between the two groups.Results The positive expression of β-catenin and p28GANK in TACE group were 77.78% and 75.56% respectively,which were significantly higher than those in pure surgery group(46.67% and 53.33% respectively,P＜0.05).In the residual hepatocellular carcinoma cells of TACE group,the positive expression of β-catenin showed correlation with the positive expression of p28GANK(Φ=0.318,P=0.033).The high expression of β-catenin and p28GANK were closely related to portal vein thrombosis and distant metastasis(P＜0.05).Conclusion The expression of β-catenin and p28GANK in the residual hepatocellular carcinoma cells were increased significantly after TACE.The high expression of β-catenin and p28GANK were closely related to portal vein thrombosis and distant metastasis.The high expression of β-catenin and p28GANK may be one of the reasons of hepatocellular carcinoma invasiveness and metastasis.

Key words: Hepatocellular carcinoma, Transcatheter arterial chemoembolization, β-catenin, p28GANK

中图分类号:

R735.7

李世杰, 杨奕, 田玉龙, 侯继野, 刘瑞宝. TACE后残余肝癌细胞β-catenin和p28GANK的表达及意义的研究[J]. 实用肿瘤学杂志, 2016, 30(5): 430-435.

LI Shijie, YANG Yi, TIAN Yulong, HOU Jiye, LIU Ruibao. The expression and significance of β-catenin and p28GANK in residual hepatocellular carcinoma cells after transcatheter arterial chemoembolization[J]. PRACTICAL ONCOLOGY JOURNAL, 2016, 30(5): 430-435.

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TACE后残余肝癌细胞β-catenin和p28GANK的表达及意义的研究

The expression and significance of β-catenin and p28GANK in residual hepatocellular carcinoma cells after transcatheter arterial chemoembolization

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