关键词: 宫颈癌, 预后, 影响因素

Abstract: Objective To explore the independent influencing factors on the survival of patients with cervical cancer.Methods Five hundreds and nintheen surgery patients with cervical cancer,and hospitalized in the Tumor Hospital Affiliated to Harbin Medical University between January 2007 and December 2008 were chosen as our research object.We analyzed the influence of different biological behaviors on the outcome of patients with cervical cancer by using univariate and multivariate COX regression,and then explored the prognostic factors of patients with cervical cancer.Results Among all biological behaviors,tumor size(P=0.015),lymph node metastasis(P＜0.001),ovarian metastasis(P＜0.001),utero-tissue infiltration(P＜0.001),vaginal stump(P=0.040),myometrial in-vasion(P=0.001)and lymph vascular space involvement(P＜0.001)affected patients′ outcomes significantly.The results of univariate COX regression showed that the tumor size(RR=2.325),histological grade(RR=3.195),lymph node metastasis(RR=3.196),ovarian metastasis(RR=7.016),utero-tissue infiltration(RR=7.487),myometrial invasion(RR=4.688)and lymph vascular space involvement(RR=4.014)were significantly associated with the prognosis of cervical cancer.In addition,the results of multivariate COX regression indicated that histological grade(RR=2.092),ovarian metastasis(RR=5.680),utero-tissue infiltration(RR=4.114),myometrial invasion(RR=2.065)and lymph vascular space involvement(RR=3.11)were significantly associated with the prognosis of cervical cancer.Conclusion Histological grade,ovarian metastasis,utero-tissue infiltration,myometrial invasion and lymph vascular space involvement were independent influencing factors of prognosis of cervical cancer.

Key words: Cervical cancer, Prognosis, Influencing factors