上皮性肿瘤的发生发展与基质之间关系的探讨

doi:10.11904/j.issn.1002-3070.2015.06.020

摘要/Abstract

摘要： 目前研究发现很多局限于原位的上皮内瘤变在一些患者中可能终生都不会被发现,例如乳腺、前列腺及肺脏等部位的病变,但是少数却不明原因的进展为恶性病变。研究发现很多侵袭性肿瘤和其癌前病变区域具有相似的基因改变,这是否为后期肿瘤的转移扩散提供了必要的前提,同样某些特定启动子的突变也驱动了癌变的发展,但是当前一种激进的观点认为并非是基因的突变影响了癌变的发生发展而是细胞的微环境抑制或者促进了肿瘤的生长。我们通常认为在肿瘤的发生发展过程中上皮细胞是先于细胞基质发生改变的,但是最近有证据表明细胞基质是率先发生变化的。本文将会集中探讨细胞基质的变化是如何影响上皮性肿瘤发生发展的,以及这会为防治上皮性肿瘤带来的新突破。

关键词: 上皮性肿瘤, 细胞基质, 区域癌化

Abstract: We have confirmed that many of the intraepithelial neoplasia confined to in situ may never be found in some patients,such as breast,prostate and lung lesions,but few of these lesions progress to malignancy are unexplained.Studies demonstrate that many invasive neoplasia and its precancerous lesions with similar genes changes,which provide the necessary premise for the late tumor metastatic,just like specific promoter mutations driving the cancer development,but the current radical view is that the mutations of the genes are not the driver of cancer development,rather the microenvironment of the cells inhibits or promotes the development of tumor.General view is that the epithelial cells are changed before the cell matrix in the development of neoplasia,but recent evidences show that the cell matrix is the first to change.This paper will focus on how matrix changes affect the epithelial tumor development,and this will bring new breakthrough for controlling epithelial tumors.

Key words: Epithelial tumors, Cell matrix, Field cancerization

中图分类号:

R73-37

庞瑶, 朱自江. 上皮性肿瘤的发生发展与基质之间关系的探讨[J]. 实用肿瘤学杂志, 2015, 29(6): 569-572.

PANG Yao, ZHU Zijiang. Epithelial tumor development and exploration on the relationship between matrix[J]. PRACTICAL ONCOLOGY JOURNAL, 2015, 29(6): 569-572.

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