关键词: 右美托咪定, 腹腔镜, 宫颈癌根治术, 全身麻醉

Abstract: Objective To investigate the influence of dexmedetomidine by continuous intravenous infusion on the recovery process of patients undergoing laparoscopic radical hysterectomy surgery under general anesthesia.Methods Eighty patients,ASAⅠ~Ⅱ,scheduled for laparoscopic radical hysterectomy surgery under general anesthesia,were randomized into group C and group D.Normal saline and dexmedetomidine at the dose of 0.6 μg.kg^-1.h^-1 were injected into different groups from 10 mins before the operation to 20 mins before the end of operation respectively.Heart rate(HR),mean arterial pressure(MAP)were recorded at following five time points:before anesthesia(T₁),10 mins before extubation(T₂),extubation(T₃),5 mins after extubation(T₄),10 mins after exbubation(T₅).The recovery time,cough reflex score,sedation-agitation scale(SAS),Ramsay score,the occurrence rate of untoward effect and the dosage of medication were observed.The observational indices were analyzed by using t-test,chi-square test,repeated measures data of ANOVA or the Mann-Whitney u test method.Results Compared with group C,during the recovery process,MAP and HR in group D was more stable.Ramsay score in group D was higher(P＜0.05).The SAS in group D was lower(P＜0.05).The sedation-agitation scale in group D was lower(P＜0.05).The occurrence rate of agitation and tachycardia was lower in group D(P＜0.05).But the occurrence rate of bradycardia was higher(P＜0.05).Meanwhile,usage amount of sevoflurane was lower in group D(P＜0.05).Conclusion Dexmedetomidine continuous intravenous infusion reduced the untoward effect of extubation,did not extend extubation time,and kept more stable haemodynamics.

Key words: Dexmedetomidine, Laparoscopic, Radical hysterectomy, General anesthesia