表皮生长因子受体与放射敏感性关系的研究进展

doi:10.11904/j.issn.1002-3070.2016.03.017

实用肿瘤学杂志 ›› 2016, Vol. 30 ›› Issue (3): 275-278.doi: 10.11904/j.issn.1002-3070.2016.03.017

表皮生长因子受体与放射敏感性关系的研究进展

刘伟综述, 李惠艳审校

哈尔滨医科大学附属肿瘤医院护理部(哈尔滨 150086)

收稿日期:2016-01-27 出版日期:2016-06-20 发布日期:2016-07-01
通讯作者: 李惠艳,E-mail:lihuiyan_1005@163.com
作者简介:刘伟,女,(1982-),本科,护师,从事放射治疗及放射治疗护理的研究

Progress in relationship between epidermal growth factor receptor and radiosensitivity

LIU Wei,LI Huiyan

Department of Nursing,The Affiliated Tumor Hospital of Harbin Medical University,Harbin 150086,China

Received:2016-01-27 Online:2016-06-20 Published:2016-07-01

摘要/Abstract

摘要： 近年来,随着对肿瘤形成机制的进一步了解以及分子生物学的进展,针对肿瘤形成发展过程中异常生物学途径的靶向治疗日益发展起来,研究表明靶向药物能够抑制肿瘤生长的活性,而且与放疗或化疗具有协同作用。但放化综合治疗会产生较大的毒副反应,从而限制了其在肿瘤治疗中的应用。靶向治疗的出现,使得放射治疗和靶向治疗联合应用于恶性肿瘤的新策略成为可能。表皮生长因子受体(Epidermal growth factor receptor,EGFR)是目前研究最多、应用最广的靶向药物治疗靶点,本文就目前肿瘤治疗中针对EGFR的靶向药物与放射治疗联合应用的机制、其与放射敏感性的关系做一综述。

关键词: 靶向治疗, 放射治疗, 表皮生长因子, 放射敏感性

Abstract: In recent years,treatment which targeting abnormal biological activity in oncogenesis and tumor progression developed with better understanding of the mechanism of oncogenesis and general progress in molecular biology.Studies have indicated that targeting drugs can inhibit the activity of tumor growth,and has a synergistic effect with radiotherapy or chemotherapy.Combined treatment with chemotherapy and radiotherapy is often used to treat a variety of tumors.However,the application of the combined treatment has been limited by its significant toxic and side effects.The emergence of targeting therapy enabled a new strategy in the treatment of malignant tumors with its combination with radiotherapy.Epidermal growth factor receptor(EGFR)is the most widely researched and applied target of targeting drugs.This review discusses the combined treatment of EGFR-targeting drugs and radiotherapy,and the relationship between EGFR and radio-sensitivity.

Key words: Target therapy, Radiotherapy, Epidermal growth factor receptor, Radiosensitity

中图分类号:

R734.2

刘伟综述, 李惠艳审校. 表皮生长因子受体与放射敏感性关系的研究进展[J]. 实用肿瘤学杂志, 2016, 30(3): 275-278.

LIU Wei,LI Huiyan. Progress in relationship between epidermal growth factor receptor and radiosensitivity[J]. PRACTICAL ONCOLOGY JOURNAL, 2016, 30(3): 275-278.

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表皮生长因子受体与放射敏感性关系的研究进展

Progress in relationship between epidermal growth factor receptor and radiosensitivity

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