乳腺Paget's病发病机制的研究进展

doi:10.11904/j.issn.1002-3070.2017.05.011

实用肿瘤学杂志 ›› 2017, Vol. 31 ›› Issue (5): 444-447.doi: 10.11904/j.issn.1002-3070.2017.05.011

乳腺Paget's病发病机制的研究进展

王烁¹ 综述, 宋燕妮^1,2,3,4 审校

1.哈尔滨医科大学附属肿瘤医院乳腺外科(哈尔滨 150081);
2.黑龙江省医学科学院;
3.哈尔滨医科大学附属第一医院美容整形外科;
4.天津医科大学附属肿瘤医院

收稿日期:2017-03-27 出版日期:2017-10-28 发布日期:2017-10-24
通讯作者: 宋燕妮,E-mail:yannimd@126.com
作者简介:王烁,女,(1991-),硕士研究生,从事乳腺癌基础与临床的研究
基金资助:
黑龙江省自然基金课题资助(H2015050);国家自然基金课题资助(H81302286);中国博士后科学基金(2016M590209);黑龙江省科研计划项目资助(201704)

Advances in pathogenesis of breast Paget's disease

WANG Shuo¹, SONG Yanni^1,2,3,4

1.Department of Breast Surgery,Harbin Medical University Cancer Hospital,Harbin 150081,China;
2.Heilongjiang Academy of Medical Sciences;
3.Department of Plastic and Cosmetic Surgery,The First Affiliated Hospital of Harbin Medical University;
4.Department of Pathology,Tianjin Medical University Cancer Hospital

Received:2017-03-27 Online:2017-10-28 Published:2017-10-24

摘要/Abstract

摘要： 乳腺Paget's病是乳腺癌的一种罕见形式,由James Paget's于1874年提出。有关乳腺Paget's病的发病机制一直备受争议,目前最主要的两种理论是嗜表皮理论和转化理论。近年来,随着对乳腺Paget's病发病机制的研究又提出了一些新的假说:因子受体学说、内分泌学说及病毒学说。乳腺Paget's病的治疗方法主要包括改良根治术、单纯乳腺切除术、保乳术等外科手术治疗,根据术后病理辅以放化疗。对于那些有强烈保乳或整形意愿的患者可给予光动力疗法进行新辅助治疗。本文通过对近几年的相关文献的阅读及整理对乳腺Paget's病发病机制的相关理论和假说进行综述。

关键词: 乳腺Paget's病, 乳腺癌, 发病机制, 治疗

Abstract: Breast paget's disease is a rare form of breast cancer,proposed by James Paget's in 1874.The pathogenesis of Paget's disease has been controversial;there are two main theories are epiphytic theory and transformation theory.In recent years,with the pathogenesis of breast Paget's disease development,some new hypotheses are input such as factor and receptor theory,endocrine theory and virus theory.Breast Paget's treatment methods= include improved radical surgery,simple breast resection,breast conserving surgery and other surgical treatment,according postoperative pathology combined with radiotherapy and chemotherapy.For those who have strong breast protection or plastic surgery will be given to patients with photodynamic therapy for neoadjuvant therapy.This paper reviews the relevant theories and hypotheses about the pathogenesis of mammary gland by collecting related literatures in recent years.

Key words: Breast paget's disease, Breast neoplasms, Pathogenesis, Treatment

中图分类号:

R737.9

王烁综述, 宋燕妮审校. 乳腺Paget's病发病机制的研究进展[J]. 实用肿瘤学杂志, 2017, 31(5): 444-447.

WANG Shuo, SONG Yanni. Advances in pathogenesis of breast Paget's disease[J]. PRACTICAL ONCOLOGY JOURNAL, 2017, 31(5): 444-447.

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乳腺Paget's病发病机制的研究进展

Advances in pathogenesis of breast Paget's disease

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