热休克蛋白70在肝细胞癌中的研究进展

doi:10.11904/j.issn.1002-3070.2017.06.009

摘要/Abstract

摘要： 热休克蛋白70(Heat shock protein 70,HSP70)是高度保守的多肽蛋白,作为分子伴侣,在蛋白稳态、细胞凋亡、侵袭、细胞信号转导中发挥重要的作用。研究表明HSP70的表达水平与肿瘤的发生发展及转归有密切联系,其在正常情况下呈低水平表达,而在肿瘤组织中呈高表达。肝细胞癌起病隐匿,相关研究报道HSP70表达水平的高低可以作为早期肝细胞癌诊断和鉴别诊断的敏感性生物学指标,同时影响着肝细胞癌患者的治疗和预后,本文就此做一综述。

关键词: 热休克蛋白70, 肝细胞癌, 诊断, 预后

Abstract: Heat shock protein 70(HSP70)is a highly conserved polypeptide protein,which plays an important role in protein homeostasis,apoptosis,invasion and cell signaling transduction.Many studies have shown that the expression level of HSP70 is closely related to the development and progression of tumor,which is a low expression in normal tissues and the overexpression in tumor tissue.Hepatocellular carcinoma(HCC)is concealed,and the related study reported that the expression of HSP70 can be used as a sensitive biological index for the diagnosis and differential diagnosis for early HCC,and also affects the treatment and prognosis of patients with HCC.This article will summary the relationship between the expression of HSP70 and HCC.

Key words: Heat shock protein 70, Hepatocellular carcinoma, Diagnosis, Prognosis

中图分类号:

R735.7

赵凌云, 齐鲁楠, 游雪梅审校. 热休克蛋白70在肝细胞癌中的研究进展[J]. 实用肿瘤学杂志, 2017, 31(6): 528-532.

ZHAO Lingyun, QI Lunan, YOU Xuemei. Research progress of heat shock protein 70 in hepatocellular carcinoma[J]. PRACTICAL ONCOLOGY JOURNAL, 2017, 31(6): 528-532.

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