关键词: 肺血栓栓塞, Ⅳ期肺癌, 肿瘤标志物, 危险因素

Abstract: Objective The aims of this study were to analyze the clinical characteristics and laboratory test results of stage Ⅳ lung cancer patients with Pulmonary thromboembolism(PTE),and to find out the risk factors for pulmonary thromboembolism.Methods A total of 70 patients with stage IV lung cancer were selected from the First Affiliated Hospital of Nan Chang University from January 2011 to October 2017.Blood routine,blood biochemistry,coagulation function,tumor markers(CEA,CA199,CA125,NSE,Cyfra211)and multi-slice spiral CT pulmonary angiography(CTPA)were collected in these patients.Univariate analysis was applied to compare the clinical features and laboratory tests between PTE and non-PTE groups.Multivariate logistic regression analysis was applied to explore significant risk factors of PTE.Results Univariate analysis showed that serum albumin,blood leukocyte,neutrophil percentage,increased Cyfra211 and abnormal tumor markers were risk factors for PTE in patients with stage IV lung cancer.Multivariate logistic regression analysis showed that the number of abnormal tumor markers ≥ 4(OR=7.016,95% CI:1.916 ~ 25.686)was an independent risk factor for PTE in stage IV lung cancer.Conclusion The number of abnormal tumor markers is an independent risk factor for pulmonary thromboembolism in stage Ⅳ lung cancer.When the number of abnormal tumor markers is ≥4,it is necessary to highly alert the possibility of stage IV lung cancer with pulmonary thromboembolism.

Key words: Pulmonary thromboembolism, Stage Ⅳ of lung cancer, Tumor markers, Risk factors