实用肿瘤学杂志 ›› 2019, Vol. 33 ›› Issue (1): 47-51.doi: 10.11904/j.issn.1002-3070.2019.01.008

• 临床研究 • 上一篇    下一篇

孕激素及雌激素受体阳性乳腺癌HER-2受体与钼靶影像学特征及临床病理学特征的相关性分析

马质莹, 尚乃舰, 蔡妙田, 沈阳, 姜智允   

  1. 哈尔滨医科大学附属肿瘤医院影像中心(哈尔滨 150081)
  • 收稿日期:2018-09-20 出版日期:2019-02-28 发布日期:2019-02-13
  • 通讯作者: 尚乃舰,E-mail:shangnaijian@126.com
  • 作者简介:马质莹,女,(1992-),硕士研究生,从事乳腺诊断方面的研究。
  • 基金资助:
    黑龙江省教育厅科学技术研究项目(12541293)

Correlation between HER-2 receptor of progesterone and estrogen receptor-positive breast cancer and mammography imaging & clinicopathological features

MA Zhingying, SHANG Naijian, CAI Miaotian, SHEN Yang, JIANG Zhiyun   

  1. Department of Radiology,Harbin Medical University Cancer Hospital,Harbin 150081,China
  • Received:2018-09-20 Online:2019-02-28 Published:2019-02-13

摘要: 目的 探讨雌激素及孕激素受体阳性乳腺癌患者钼靶影像学特征及临床征象与HER-2受体表达之间的关系。方法 2017年7月—2017年9月在我院收治入院的111例雌激素及孕激素受体阳性乳腺癌患者术前均进行钼靶检查,术后病理进行免疫组织化学分析,分别统计患者临床病理特征及钼靶影像学相关特征。分析患者临床病理特征及钼靶影像学相关征象与HER-2表达的关系。结果 111名患者中HER-2阳性患者34名,淋巴结转移情况、肿块是否伴钙化、肿块边缘情况、钙化的有无、钙化形态、血管是否增粗与HER-2过表达相关(P<0.05)。三阳性乳腺癌患者钼靶更容易表现为淋巴结肿大、肿块伴钙化或单纯钙化、边缘出现毛刺、颗粒样钙化、血管增粗的形式。结论 雌激素及孕激素受体阳性乳腺癌患者钼靶中淋巴结转移情况、肿瘤是否伴钙化、肿瘤边缘、钙化有无、钙化形态及周围血管增粗均能在一定程度上反映HER-2表达情况,临床可根据患者的临床病理特征及钼靶的影像学表现推测肿瘤的生物学行为及特征,为乳腺癌患者治疗及评估预后提供方向。

关键词: 乳腺癌, 钼靶, HER-2

Abstract: Objective The of this study was to investigate the relationship between the molybdenum target imaging features and clinical signs of mammography,and the expression of HER-2 receptor in breast cancer patients with positive receptors of estrogen and progesterone.Methods One hundred and eleven patients with estrogen and progesterone receptor-positive breast cancer who were admitted to our hospital from July to September 2017 were examined with mammography before operation.Immunohistochemical analysis was performed on breast cancer tissues.Pathological features and features related to mammography were analyzed after operation.The relationship between clinicopathological features and mammography-related signs,and HER-2 expression was also analyzed statistically.Results Of the 111 patients,34 were HER-2 positive patients.There were significant difference between the observed indicators and the over-expression of HER-2(P<0.05).These indicators included lymph node metastasis,calcification of the mass,margin of the mass,the shape of calcification,and the blood status of vessels.The mammography of patients with triple positive breast cancer is more likely to manifest as lymph node enlargement,mass with calcification or simple calcification,marginal burrs,granular calcification,and vascular thickening.Conclusion The expression of HER-2 in breast cancer patients with positive estrogen and progesterone receptors can be reflected to some extent by lymph node metastasis,tumor with calcification,tumor margin,calcification,calcification morphology and peripheral blood vessel thickening.In terms of clinical conditions,The biological behavior and characteristics of tumor can be inferred based on the clinicopathological features of the patient and the imaging findings of the mammography,providing a direction for the treatment and evaluation of prognosis in breast cancer patients.

Key words: Breast cancer, Molybdenum target, HER-2

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