乳腺癌化疗患者生存质量及影响因素分析

doi:10.11904/j.issn.1002-3070.2019.02.010

实用肿瘤学杂志 ›› 2019, Vol. 33 ›› Issue (2): 149-154.doi: 10.11904/j.issn.1002-3070.2019.02.010

乳腺癌化疗患者生存质量及影响因素分析

马志杰^1,2, 王帆¹, 赵亚双¹

1.哈尔滨医科大学流行病与卫生统计教研室(哈尔滨 150081);
2.黑龙江省疾病预防控制中心

收稿日期:2018-01-24 修回日期:2019-01-14 出版日期:2019-04-20 发布日期:2019-04-25
通讯作者: 赵亚双,E-mail:yashuang_zhao@163.com
作者简介:马志杰,女,(1986-),硕士,中级主管医师,从事公共卫生的研究

Analysis of life quality and influencing factors in breast cancer patients with chemotherapy

MA Zhijie^{1, 2}, WANG Fan¹, ZHAO Yashuang¹

1.Department of Epidemiological and Health Statistics, Harbin Medical University, Harbin 150081, China;
2.Heilongjiang Provincial Center for Disease Control and Prevention

Received:2018-01-24 Revised:2019-01-14 Online:2019-04-20 Published:2019-04-25

摘要/Abstract

摘要： 目的调查和了解乳腺癌化疗患者的生存质量及其影响因素。方法以欧洲研究和治疗协会的QLQ-C30和QLQ-BR23组成EORTC-BR53量表为主要依据设计调查问卷,对乳腺癌化疗患者的生存质量进行调查,应用秩和检验评价乳腺癌化疗患者的生存质量,应用等级Logistic回归分析影响预后生存质量的因素。结果诊断与调查时间间隔小于35个月,36~59个月和大于60个月三组中QLQ-BR23量表的性乐趣得分中位数分别为0,0和66.67(P＜0.05),症状量表脱发引起烦恼得分中位数分别为33.33,33.33和10.33(P＜0.05)。改良根治术、区段加前哨和保乳患者的QLQ-C30量表躯体功能得分中位数分别为66.67,66.67和73.33(P＜0.05);改良根治术的恶心呕吐得分为16.67,其他组为0分(P＜0.05);QLQ-BR23三组体形得分中位数分别为91.67,100和100(P＜0.05);性功能得分分别为0,16.67和50(P＜0.05);性乐趣得分中位数分别为0,33.33和66.67(P＜0.05)。对生存质量总症状进行分析,因病借钱和病理分类是化疗的乳腺癌患者生存质量总症状的影响因素(P＜0.05)。结论化疗的乳腺癌患者生存质量主要与患者的病理分期、是否有经济压力密切相关。

关键词: 乳腺癌, 生命质量, 影响因素, 化疗

Abstract: Objective The objective of this study was to investigate and understand the life quality and its influencing factors in breast cancer patients with chemotherapy. Methods Based on the European Research and Treatment Association,the EORTC-BR53 scale consisting of QLQ-C30 and QLQ-BR23 was used as the main basis to design a questionnaire to investigate the life quality of breast cancer patients with chemotherapy.The rank sum test was used to evaluate the survival of breast cancer patients with chemotherapy.The grade logistics univariate and multivariate analyses were used to analyze the factors of prognosis and life quality of breast cancer patients. Results The median fun scores of QLQ-BR23 scale in the groups of ＜35 months,36~59 months and more than 60 months were 0,0,and 66.67,respectively(P＜0.05).The median scores of annoy caused by alopecia were 33.33,33.33,and 10.33 in three groups mentioned above,respectively(P＜0.05).The median scores of physical function of QLQ-C30 scale for modified radical mastectomy,segment plus sentinel and breast-conserving patients were 66.67,66.67,and 73.33,respectively(P＜0.05).The median scores of nausea and vomiting in the modified radical mastectomy was 16.67,and others were 0;the median scores of shape physique of QLQ-BR23 in three groups were 91.67,100 and 100,respectively(P＜0.05);the median scores of sexual function were 0,16.67 and 50,respectively(P＜0.05),and the median scores of sexual fun were 0,33.33 and 66.67,respectively(P＜0.05).To analyze the total symptoms of life quality,causing borrow money and pathological classification were the factors affecting the total life quality of breast cancer patients with chemotherapy(P＜0.05).The total symptoms of life quality were analyzed.Univariate analysis showed that borrows money due to illness and ductal carcinoma in pathological classification had significant. Conclusion The life quality of breast cancer patients with chemotherapy is mainly related to the pathological stage of patients and whether they have economic pressure.

Key words: Breast cancer, Quality of life, Influencing factors, Chemotherapy

中图分类号:

R737.9

马志杰, 王帆, 赵亚双. 乳腺癌化疗患者生存质量及影响因素分析[J]. 实用肿瘤学杂志, 2019, 33(2): 149-154.

MA Zhijie, WANG Fan, ZHAO Yashuang. Analysis of life quality and influencing factors in breast cancer patients with chemotherapy[J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(2): 149-154.

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乳腺癌化疗患者生存质量及影响因素分析

Analysis of life quality and influencing factors in breast cancer patients with chemotherapy

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