比较18F-FDG PET/CT显像IHP、Deauville和△SUVmax在恶性淋巴瘤早中期治疗敏感性判定和预后评估中的应用价值

doi:10.11904/j.issn.1002-3070.2019.02.012

实用肿瘤学杂志 ›› 2019, Vol. 33 ›› Issue (2): 160-166.doi: 10.11904/j.issn.1002-3070.2019.02.012

比较¹⁸F-FDG PET/CT显像IHP、Deauville和△SUVmax在恶性淋巴瘤早中期治疗敏感性判定和预后评估中的应用价值

李雪蓉^1,2, 冯洪燕^1,2, 周莹^1,2, 李超群^1,2, 兰晓莉³, 卜丽红^1,2

1.武汉大学人民医院PET中心(武汉 430060);
2.武汉大学人民医院分子影像中心;
3.华中科技大学同济医学院附属协和医院核医学科

收稿日期:2018-12-12 修回日期:2019-01-22 出版日期:2019-04-20 发布日期:2019-04-25
通讯作者: 卜丽红,E-mail:bulihongs@126.com
作者简介:李雪蓉,女,(1994-),硕士研究生,从事恶性淋巴瘤的研究

Comparison of ¹⁸F-FDG PET/CT imaging IHP,Deauville and △SUVmax image analysis methods in the evaluation of the early and mid-stage treatment sensitivity and prognosis in malignant lymphoma

LI Xuerong^{1, 2}, FENG Hongyan^{1, 2}, ZHOU Ying^{1, 2}, LI Chaoqun^{1, 2}, LAN Xiaoli³, BU Lihong^{1, 2}

1.The Center of PET, Renmin Hospital of Wuhan University, Wuhan 430060, China;
2.The Center of Molecular Imaging, Renmin Hospital of Wuhan University;
3.Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Received:2018-12-12 Revised:2019-01-22 Online:2019-04-20 Published:2019-04-25

摘要/Abstract

摘要： 目的探讨IHP标准视觉判断法、Deauville 5分法和最大标准摄取值下降率(△SUVmax)法三种图像分析方法对恶性淋巴瘤患者的治疗早-中期敏感性判定和预后评估的价值。方法选取符合入选标准的恶性淋巴瘤患者51例。分别采用IHP标准视觉判断法、Deauville 5分法对患者PET/CT图像进行分析。计算患者治疗前、治疗早中期△SUVmax,通过ROC曲线取得PET/CT对治疗早-中期敏感性判定和预后评估△SUVmax最佳临界值。对比这三种方法诊断效能之间的差异,并采用Kaplan-Meier生存分析、单因素和多因素Cox比例风险回归模型分析恶性淋巴瘤患者DFS的影响因素。结果 ROC曲线分析结果显示△SUVmax为56.95%时PET/CT诊断效能最佳。IHP标准视觉判断法、Deauville 5分法与△SUVmax法对淋巴瘤治疗早-中期疗效评估均可获得较高的灵敏度和阴性预测值,其中△SUVmax法的阳性预测值和准确度均高于另外两种方法。结论 IHP标准视觉判断法、Deauville 5分法和△SUVmax在淋巴瘤治疗早-中期的疗效评估和预测预后方面均有较高的临床价值,均可作为判断预后的独立危险因素。

关键词: 淋巴瘤, ¹⁸F-FDG PET/CT, IHP标准视觉判断法, Deauville 5分法, 最大标准摄取值下降率

Abstract: Objective The aim of this study was to explore the values of IHP standard visual judgment,deauville(5-porint scoring and 5-PS)and maximum standard uptake rate(△SUVmax)image methods in the evaluation of early-and mid-term sensitivity determination and prognosis in malignant lymphoma patients. Methods A total of 51 patients with lymphoma who met the inclusion criteria were selected for retrospectively analyses.PET/CT images of patients were analyzed by IHP standard visual judgment and deauville five-point methods.The △SUVmax value of the patient in the early and middle stages of treatment was calculated before treatment, and the optimal cut-off value of PET/CT for early- and mid-term sensitivity determination and prognosis of evaluation △SUVmax was obtained by ROC curve.The differences between the diagnostic efficiencies of three methods were compared.The Kaplan-Meier analysis and Cox proportional hazard regression model were used for univariate and multivariate analyses. Results The results of ROC curve analysis showed that PET/CT had the best diagnostic efficiency when △SUVmax was 56.95%.IHP standard visual judgment,deauville quintile and △SUVmax methods could obtain high sensitivity and negative predictive values for the early-term treatment of lymphoma treatment.The positive predictive values and accuracy of △SUVmax method were higher than other two methods. Conclusion IHP standard visual judgment,deauville 5,and △SUVmax have high clinical values in the evaluation of early and middle stage of lymphoma treatment and prognosis.They can be used as independent risk factors for prognosis.

Key words: Lymphoma, ¹⁸F-FDG PET/CT, IHP, Deauville 5-point Scoring, △SUVmax

中图分类号:

R733.4

李雪蓉, 冯洪燕, 周莹, 李超群, 兰晓莉, 卜丽红. 比较¹⁸F-FDG PET/CT显像IHP、Deauville和△SUVmax在恶性淋巴瘤早中期治疗敏感性判定和预后评估中的应用价值[J]. 实用肿瘤学杂志, 2019, 33(2): 160-166.

LI Xuerong, FENG Hongyan, ZHOU Ying, LI Chaoqun, LAN Xiaoli, BU Lihong. Comparison of ¹⁸F-FDG PET/CT imaging IHP,Deauville and △SUVmax image analysis methods in the evaluation of the early and mid-stage treatment sensitivity and prognosis in malignant lymphoma[J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(2): 160-166.

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比较¹⁸F-FDG PET/CT显像IHP、Deauville和△SUVmax在恶性淋巴瘤早中期治疗敏感性判定和预后评估中的应用价值

Comparison of ¹⁸F-FDG PET/CT imaging IHP,Deauville and △SUVmax image analysis methods in the evaluation of the early and mid-stage treatment sensitivity and prognosis in malignant lymphoma

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