环状RNA与卵巢癌研究新进展

doi:10.11904/j.issn.1002-3070.2019.06.014

摘要/Abstract

摘要： 环状RNA(Circular RNAs,circRNA)是一种特殊的环状非编码RNA,不易被RNase降解,在许多肿瘤的发生和发展中起着重要作用。在这篇综述中我们主要总结了环状RNA在卵巢癌中表达、作用及作用机制的研究进展,以期探讨环状RNA在卵巢癌诊断治疗方面的开发前景。

关键词: 环状RNA, 卵巢癌, 表达, 作用, 开发前景

Abstract: Circular RNAs(circRNAs)are a special type of circular non-coding RNA that is not easily degraded by RNase and plays an important role in the occurrence and development of many tumors.In this review,we mainly summarized the research progress in expression,action and mechanism of circRNA in ovarian cancer,in order to explore the developmental prospect of circRNAs in the diagnosis and treatment of ovarian cancer.

Key words: CircRNA, Ovarian cancer, Expression, Effect, Developmental prospect

中图分类号:

邓明新, 张颖. 环状RNA与卵巢癌研究新进展[J]. 实用肿瘤学杂志, 2019, 33(6): 549-552.

DENG Mingxin, ZHANG Ying. Research progress of circRNAs and ovarian cancer[J]. Journal of Practical Oncology, 2019, 33(6): 549-552.

0
/ / 推荐

导出引用管理器 EndNote|Reference Manager|ProCite|BibTeX|RefWorks

链接本文: http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/10.11904/j.issn.1002-3070.2019.06.014

http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/Y2019/V33/I6/549

参考文献

1 Wu S,Li H,Lu C,et al.Aberrant expression of hsa_circ-0025036 in lung adenocarcinoma and its potential roles in regulating cell proliferation and apoptosis[J].Biol Chem,2018,399(12):1457-1467.
2 Bao L,Zhong J,Pang L.Upregulation of circular RNA VPS13C-has-circ-001567 promotes ovarian cancer cell proliferation and invasion[J].Cancer Biother Radiopharm,2018,211(14):102-106.
3 House CD,Jordan E,Hernandez L,et al.NFkappaB promotes ovarian tumorigenesis via classical pathways that support proliferative cancer cells and alternative pathways that support ALDH(+)cancer stem-like cells[J].Cancer Res,2017,77(24):6927-6940.
4 Gao J,Zhu Y,Nilsson M,et al.TGF-beta isoforms induce EMT independent migration of ovarian cancer cells[J].Cancer Cell Int,2014,14(1):72.
5 Chen Q,Zhang J,He Y,et al.Hsa_circ_0061140 knockdown reverses FOXM1-mediated cell growth and metastasis in ovarian cancer through miR-370 sponge activity[J].Mol Ther Nucleic Acids,2018,13:55-63.
6 Hu J,Wang L,Chen J,et al.The circular RNA circ-ITCH suppresses ovarian carcinoma progression through targeting miR-145/RASA1 signaling[J].Biochem Biophys Res Commun,2018,505(1):222-228.
7 李文辉,吕博文,钱钧,等.MicroRNA-150对上皮性卵巢癌细胞增殖、凋亡和侵袭转移能力的影响[J].实用肿瘤学杂志,2018,32(3):208-213.
8 吕博文,钱钧,王杰,等.miR-455-5p在上皮性卵巢癌中表达研究及其靶基因功能分析[J].实用肿瘤学杂志,2019,33(2):115-121.
9 Liu N,Zhang J,Zhang LY,et al.CircHIPK3 is upregulated and predicts a poor prognosis in epithelial ovarian cancer[J].Eur Rev Med Pharmacol Sci,2018,22(12):3713-3718.
10 Zhang M,Xia B,Xu Y,et al.Circular RNA(hsa_circ_0051240)promotes cell proliferation,migration and invasion in ovarian cancer through miR-637/KLK4 axis[J].Artif Cells Nanomed Biotechnol,2019,47(1):1224-1233.
11 Tao H,Xiong Q,Zhang F,et al.Circular RNA profiling reveals chi_circ_0008219 function as microRNA sponges in pre-ovulatory ovarian follicles of goats(Capra hircus)[J].Genomics,2017,17(14):13-14.
12 Gao Y,Zhang C,Liu Y,et al.Circular RNA profiling reveals circRNA1656 as a novel biomarker in high grade serous ovarian cancer[J].Biosci Trends,2019,13(2):204-211.
13 Ning L,Long B,Zhang W,et al.Circular RNA profiling reveals circEXOC6B and circN4BP2L2 as novel prognostic biomarkers in epithelial ovarian cancer[J].Int J Oncol,2018,53(6):2637-2646.
14 Mak CS,Yung MM,Hui LM,et al.MicroRNA-141 enhances anoikis resistance in metastatic progression of ovarian cancer through targeting KLF12/Sp1/survivin axis[J].Mol Cancer,2017,16(1):11.
15 Jaarsveld MT,Helleman J,Boersma AW,et al.miR-141 regulates KEAP1 and modulates cisplatin sensitivity in ovarian cancer cells[J].Oncogene,2013,32(36):4284-4293.
16 Huang XY,Huang ZL,Xu YH,et al.Comprehensive circular RNA profiling reveals the regulatory role of the circRNA-100338/miR-141-3p pathway in hepatitis B-related hepatocellular carcinoma[J].Sci Rep,2017,7(1):5428.
17 Zhou B,Yu JW.A novel identified circular RNA,circRNA_010567,promotes myocardial fibrosis via suppressing miR-141 by targeting TGF-beta1[J].Biochem Biophys Res Commun,2017,487(4):769-775.
18 Nakano H,Yamada Y,Miyazawa T,et al.Gain-of-function microRNA screens identify miR-193a regulating proliferation and apoptosis in epithelial ovarian cancer cells[J].Int J Oncol,2013,42(6):1875-1882.
19 Liu X,Liu B,Zhou M,et al.Circular RNA HIPK3 regulates human lens epithelial cells proliferation and apoptosis by targeting the miR-193a/CRYAA axis[J].Biochem Biophys Res Commun,2018,503(4):2277-2285.
20 Suto T,Yokobori T,Yajima R,et al.MicroRNA-7 expression in colorectal cancer is associated with poor prognosis and regulates cetuximab sensitivity via EGFR regulation[J].Carcinogenesis,2015,36(3):338-345.
21 Skirnisdottir I,Akerud H,Seidal T.Clinical significance of growth factor receptor EGFR and angiogenesis regulator VEGFR2 in patients with ovarian cancer at FIGO stages I-II[J].Int J Oncol,2018,53(4):1633-1642.
22 Zhou X,Jiang L,Fan G,et al.Role of the ciRS-7/miR-7 axis in the regulation of proliferation,apoptosis and inflammation of chondrocytes induced by IL-1beta[J].Int Immunopharmacol,2019,71:233-240.
23 Zhang W,Wang Q,Yu M,et al.MicroRNA-145 function as a cell growth repressor by directly targeting c-Myc in human ovarian cancer[J].Technol Cancer Res Treat,2014,13(2):161-168.
24 Xie H,Ren X,Xin S,et al.Emerging roles of circRNA_001569 targeting miR-145 in the proliferation and invasion of colorectal cancer[J].Oncotarget,2016,7(18):26680-26691.
25 Zhen YB,Guo XL,Xu B,et al.Gene expression profiling analysis of the role of miR-22 in clear cell ovarian cancer[J].Neoplasma,2016,63(6):856-864.
26 Li Y,Gu Y,Tang N,et al.MiR-22-notch signaling pathway is involved in the regulation of the apoptosis and autophagy in human ovarian cancer cells[J].Biol Pharm Bull,2018,41(8):1237-1242.
27 Wang M,Chen B,Ru Z,et al.CircRNA circ-ITCH suppresses papillary thyroid cancer progression through miR-22-3p/CBL/beta-catenin pathway[J].Biochem Biophys Res Commun,2018,504(1):283-288.
28 Yin G,Chen R,Alvero AB,et al.TWISTing stemness,inflammation and proliferation of epithelial ovarian cancer cells through MIR199A2/214[J].Oncogene,2010,29(24):3545-3553.
29 Li F,Ma K,Sun M,et al.Identification of the tumor-suppressive function of circular RNA ITCH in glioma cells through sponging miR-214 and promoting linear ITCH expression[J].Am J Transl Res,2018,10(5):1373-1386.
30 Gong C,Yang Z,Wu F,et al.miR-17 inhibits ovarian cancer cell peritoneal metastasis by targeting ITGA5 and ITGB1[J].Oncology Reports,2016,36(4):2177-2183.
31 Fang Y,Xu C,Fu Y.MicroRNA-17-5p induces drug resistance and invasion of ovarian carcinoma cells by targeting PTEN signaling[J].J Biol Res,2015,22(1):1-10.
32 Zhao H,Bi T,Qu Z,et al.Expression of miR-224-5p is associated with the original cisplatin resistance of ovarian papillary serous carcinoma[J].Oncology Reports,2014,32(3):1003.
33 Young TW,Rosen DG,Mei FC,et al.Up-regulation of tumor susceptibility gene 101 conveys poor prognosis through suppression of p21 expression in ovarian cancer[J].Clin Cancer Res,2007,13(13):3848.
34 Schöndorf T,Göhring UJ,Roth G,et al.Time to progression is dependent on the expression of the tumour suppressor PTEN in ovarian cancer patients[J].Eur J Clin Invest,2015,33(3):256-260.
35 Yang C,Yuan W,Yang X,et al.Circular RNA circ-ITCH inhibits bladder cancer progression by sponging miR-17/miR-224 and regulating p21,PTEN expression[J].Mol Cancer,2018,17(1):19.
36 Kapetanakis NI,Uzan C,Jimenez-Pailhes AS,et al.Plasma miR-200b in ovarian carcinoma patients:distinct pattern of pre/post-treatment variation compared to CA-125 and potential for prediction of progression-free survival[J].Oncotarget,2015,6(34):36815-36824.
37 Wang BG,Li JS,Liu YF,et al.MicroRNA-200b suppresses the invasion and migration of hepatocellular carcinoma by downregulating RhoA and circRNA-000839[J].Tumour Biol,2017,39(7):13933-14007.
38 Chan JK,Kiet TK,Blansit K,et al.MiR-378 as a biomarker for response to anti-angiogenic treatment in ovarian cancer[J].Gynecol Oncol,2014,133(3):568-574.
39 Wei X,Li H,Yang J,et al.Circular RNA profiling reveals an abundant circLMO7 that regulates myoblasts differentiation and survival by sponging miR-378a-3p[J].Cell Death Dis,2017,8(10):3153.

[1]	黄梨, 龙佑梅, 付义霞, 夏良斌. 紫檀芪对卵巢癌SKOV3细胞凋亡和糖酵解的影响及机制研究[J]. 实用肿瘤学杂志, 2019, 33(6): 502-507.
[2]	许健, 詹月萍, 蒋元烨, 曹勤. α-常春藤皂苷的抗肿瘤药理作用研究进展[J]. 实用肿瘤学杂志, 2019, 33(6): 553-556.
[3]	张慧婷, 娄阁. 卵巢癌肿瘤微环境的三维细胞培养模型研究进展[J]. 实用肿瘤学杂志, 2019, 33(6): 557-560.
[4]	宋玲, 付琼. 紫云英苷通过上调PHD2抑制缺氧诱导的卵巢癌细胞增殖和侵袭[J]. 实用肿瘤学杂志, 2019, 33(5): 407-414.
[5]	张蓓蕾, 李怡, 吴涛, 姜锋, 赵宏喜, 李艳红. 血根碱通过诱导细胞凋亡抑制卵巢癌肿瘤生长的机制研究[J]. 实用肿瘤学杂志, 2019, 33(4): 305-309.
[6]	侯玉雪,李晓莉. Wnt7a与恶性肿瘤的关系及研究进展[J]. 实用肿瘤学杂志, 2019, 33(3): 271-275.
[7]	吕博文, 钱钧, 王杰, 钱景荣, 卢莹莹, 苏丽菊, 杨桐树, 李文辉. miR-455-5p在上皮性卵巢癌中表达研究及其靶基因功能分析[J]. 实用肿瘤学杂志, 2019, 33(2): 115-121.
[8]	常晓霞综述, 宋冰冰, 刘家仁审校. 植物化学物增加肿瘤细胞对化疗药物敏感性的研究进展[J]. 实用肿瘤学杂志, 2019, 33(1): 67-72.
[9]	邢志超综述, 麦威审校. 脂肪肉瘤潜在作用靶点的研究进展[J]. 实用肿瘤学杂志, 2019, 33(1): 82-86.
[10]	宋玲, 付琼. 紫云英苷通过抑制HIF-1α诱导的糖酵解途径发挥抗卵巢肿细胞作用的研究[J]. 实用肿瘤学杂志, 2018, 32(6): 503-509.
[11]	胡小军, 李霄. Pim-1在原发性肝细胞癌组织中的表达情况及其临床意义[J]. 实用肿瘤学杂志, 2018, 32(6): 527-532.
[12]	艾廉杰综述, 朴大勋审校. 结肠癌中相关锌指蛋白的研究进展[J]. 实用肿瘤学杂志, 2018, 32(6): 567-570.
[13]	王元综述, 孙轶华审校. β-连环蛋白在软组织肿瘤中的研究进展[J]. 实用肿瘤学杂志, 2018, 32(5): 455-459.
[14]	姜亮亮综述, 王晶审校. 上皮性卵巢癌远处转移的诊治进展[J]. 实用肿瘤学杂志, 2018, 32(5): 480-482.
[15]	梁冠盈, 迟秋君, 李晓梅. 伏立诺他对卵巢癌SKOV3细胞增殖和凋亡的影响及机制研究[J]. 实用肿瘤学杂志, 2018, 32(4): 298-302.