6A甲基化修饰在肿瘤中的作用

doi:10.11904/j.issn.1002-3070.2020.05.018

摘要/Abstract

摘要： N6-甲基腺苷(m6A)修饰作为表观遗传学研究的一部分,是最常见的RNA修饰之一,近年来受到越来越多的关注。m6A甲基化修饰由甲基转移酶、去甲基化酶及阅读蛋白共同动态调节。大量研究表明,m6A甲基化修饰可以通过调节与癌症相关的生物学功能来影响癌症的发生发展。本文简要介绍了m6A甲基化修饰,并对m6A甲基化修饰在不同肿瘤中的作用进行综述。

关键词: m6A甲基化修饰, 甲基转移酶, 去甲基化酶, 阅读蛋白

Abstract: N6-methyladenosine(m6A)modification,as a part of epigenetic research,is one of the most common RNA modifications,and has attracted more and more attention in recent years.m6A methylation modification is dynamically regulated by methyltransferase,demethylase and reading protein.A large number of studies have shown that m6A methylation modification can affect the occurrence and development of cancer by regulating the biological functions related to cancer.This article briefly introduces m6A methylation modification and reviews the role of m6A methylation modification in different tumors.

Key words: m6A methylation, Methyltransferase, Demethylase, Reading protein

中图分类号:

R730.5

李慧, 庞达. 6A甲基化修饰在肿瘤中的作用[J]. 实用肿瘤学杂志, 2020, 34(5): 480-484.

LI Hui, PANG Da. The role of m6A methylation modification in tumors[J]. Journal of Practical Oncology, 2020, 34(5): 480-484.

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http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/Y2020/V34/I5/480

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