RUNX1在肺癌中的研究进展

doi:10.11904/j.issn.1002-3070.2022.06.016

实用肿瘤学杂志 ›› 2022, Vol. 36 ›› Issue (6): 576-579.doi: 10.11904/j.issn.1002-3070.2022.06.016

RUNX1在肺癌中的研究进展

陈俊慧¹, 刘思雨²(综述), 贺长军¹(审校)

1.哈尔滨医科大学附属肿瘤医院胸外科(哈尔滨 150081);
2.哈尔滨医科大学附属肿瘤医院泌尿外科

收稿日期:2022-06-07 修回日期:2022-10-25 出版日期:2022-12-28 发布日期:2023-01-06
通讯作者: 贺长军,E-mail:he_changjun_cool@126.com
作者简介:陈俊慧,女,(1996-),硕士研究生,从事肺部肿瘤方面的研究

Research progress of RUNX1 in lung cancer

CHEN Junhui¹, LIU Siyu², HE Changjun¹

1. Department of Thoracic Surgery,Harbin Medical University Cancer Hospital,Harbin 150081,China;
2. Department of Urinary Surgery,Harbin Medical University Cancer Hospital

Received:2022-06-07 Revised:2022-10-25 Online:2022-12-28 Published:2023-01-06

摘要/Abstract

摘要： 矮小相关转录因子1(Runt-related transcription factor 1,RUNX1)属于RUNX家族成员,是脊椎动物的关键调控蛋白之一。RUNX1参与胚胎发育、造血、血管生成、肿瘤发生和免疫反应。过去,研究主要集中在RUNX1在急性白血病中的作用机制,关于RUNX1在肺癌病理过程中作用的研究报道较少。最新的研究表明,RUNX1在人类发育和出生后肺的间质和上皮细胞中均有高表达,同时与肺癌的发生和进展有着密不可分的关系。本文就RUNX1在肺癌发生发展中的研究进展作一综述。

关键词: 肺癌, 矮小相关转录因子1, 研究进展

Abstract: Runt-related transcription factor 1(RUNX1),a member of the RUNX family,is one of the key regulatory proteins in vertebrates.RUNX1 is involved in embryonic development,haematopoiesis,angiogenesis,tumorigenesis and immune response.In the past decades,the research mainly focused on the mechanism of RUNX1 in acute leukaemia,and there were few reports on the role of RUNX1 in the pathological process of lung cancer.The latest research shows that RUNX1 is highly expressed in the mesenchymal and epithelial cells of the human development and postnatal lung,and is closely related to the occurrence and progression of lung cancer.This article reviews the research progress of RUNX1 in the occurrence and progress of lung cancer.

Key words: Lung cancer, Runt-related transcription factor 1, Research progress

中图分类号:

R734.2

陈俊慧, 刘思雨, 贺长军. RUNX1在肺癌中的研究进展[J]. 实用肿瘤学杂志, 2022, 36(6): 576-579.

CHEN Junhui, LIU Siyu, HE Changjun. Research progress of RUNX1 in lung cancer[J]. Journal of Practical Oncology, 2022, 36(6): 576-579.

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http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/Y2022/V36/I6/576

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RUNX1在肺癌中的研究进展

Research progress of RUNX1 in lung cancer

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