1 Sung H,Ferlay J,Siegel RL,et al.Global cancer statistics 2020:globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J].CA Cancer J Clin,2021,71(3):209-249. 2 Abbott M,Ustoyev Y.Cancer and the immune system:the history and background of immunotherapy[J].Semin Oncol Nurs,2019,35(5):150923. 3 Park R,Williamson S,Kasi A,et al.Immune therapeutics in the treatment of advanced gastric and esophageal cancer[J].Anticancer Res,2018,38(10):5569-5580. 4 Muro K,Chung HC,Shankaran V,et al.Pembrolizumab for patients with PD-L1-positive advanced gastric cancer(KEYNOTE-012):a multicentre,open-label,phase 1b trial[J].Lancet Oncol,2016,17(6):717-726. 5 Fuchs CS,Doi T,Jang RW,et al.Safety and efficacy of pembrolizumab monotherapy in patients with previously treated advanced gastric and gastroesophageal junction cancer:phase 2 clinical KEYNOTE-059 trial[J].JAMA Oncol,2018,4(5):e180013. 6 Kang YK,Boku N,Satoh T,et al.Nivolumab in patients with advanced gastric or gastro-oesophageal junction cancer refractory to,or intolerant of,at least two previous chemotherapy regimens(ONO-4538-12,ATTRACTION-2):a randomised,double-blind,placebo-controlled,phase 3 trial[J].Lancet,2017,390(10111):2461-2471. 7 Boku N,Satoh T,Ryu MH,et al.Nivolumab in previously treated advanced gastric cancer(ATTRACTION-2):3-year update and outcome of treatment beyond progression with nivolumab[J].Gastric Cancer,2021,24(4):946-958. 8 Moehler M,Dvorkin M,Boku N,et al.Phase III trial of avelumab maintenance after first-line induction chemotherapy versus continuation of chemotherapy in patients with gastric cancers:results from javelin gastric 100[J].J Clin Oncol,2021,39(9):966-977. 9 Hosseini A,Gharibi T,Marofi F,et al.CTLA-4:From mechanism to autoimmune therapy[J].Int Immunopharmacol,2020,80:106221. 10 Ralph C,Elkord E,Burt DJ,et al.Modulation of lymphocyte regulation for cancer therapy:a phase II trial of tremelimumab in advanced gastric and esophageal adenocarcinoma[J].Clin Cancer Res,2010,16(5):1662-1672. 11 Sun JM,Shen L,Shah MA,et al.Pembrolizumab plus chemotherapy versus chemotherapy alone for first-line treatment of advanced oesophageal cancer(KEYNOTE-590):a randomised,placebo-controlled,phase 3 study[J].Lancet,2021,398(10302):759-771. 12 Shitara K,Van Cutsem E,Bang YJ,et al.Efficacy and safety of pembrolizumab or pembrolizumab plus chemotherapy vs chemotherapy alone for patients with first-line,advanced gastric cancer:the KEYNOTE-062 phase 3 randomized clinical trial[J].JAMA Oncol,2020,6(10):1571-1580. 13 Janjigian YY,Shitara K,Moehler M,et al.First-line nivolumab plus chemotherapy versus chemotherapy alone for advanced gastric,gastro-oesophageal junction,and oesophageal adenocarcinoma(CheckMate 649):a randomised,open-label,phase 3 trial[J].Lancet,2021,398(10294):27-40. 14 LIU T,BAI Y,LIN X,et al.First-line nivolumab plus chemotherapy vs chemotherapy in patients with advanced gastric,gastroesophageal junction and esophageal adenocarcinoma:CheckMate 649 Chinese subgroup analysis[J].Int J Cancer,2023,152(4):749-760. 15 JIANG H,ZHENG Y,QIAN J,et al.Safety and efficacy of sintilimab combined with oxaliplatin/capecitabine as first-line treatment in patients with locally advanced or metastatic gastric/gastroesophageal junction adenocarcinoma in a phase Ib clinical trial[J].BMC Cancer,2020,20(1):760. 16 XU J,JIANG H,PAN Y,et al.LBA53 Sintilimab plus chemotherapy(chemo)versus chemo as first-line treatment for advanced gastric or gastroesophageal junction(G/GEJ)adenocarcinoma(ORIENT-16):First results of a randomized,double-blind,phase III study[J].Annals of Oncology,2021,32:S1331. 17 WANG F,WEI XL,WANG FH,et al.Safety,efficacy and tumor mutational burden as a biomarker of overall survival benefit in chemo-refractory gastric cancer treated with toripalimab,a PD-1 antibody in phase Ib/II clinical trial NCT02915432[J].Ann Oncol,2019,30(9):1479-1486. 18 Tabernero J,Bang YJ,Van Cutsem E,et al.KEYNOTE-859:a Phase III study of pembrolizumab plus chemotherapy in gastric/gastroesophageal junction adenocarcinoma[J].Future Oncol,2021,17(22):2847-2855. 19 Rotte A.Combination of CTLA-4 and PD-1 blockers for treatment of cancer[J].J Exp Clin Cancer Res,2019,38(1):255. 20 Keam S J.Cadonilimab:First Approval[J].Drugs,2022,82(12):1333-1339. 21 Janjigian YY,Bendell J,Calvo E,et al.CheckMate-032 study:efficacy and safety of nivolumab and nivolumab plus ipilimumab in patients with metastatic esophagogastric cancer[J].J Clin Oncol,2018,36(28):2836-2844. 22 Bang YJ,Van Cutsem E,Feyereislova A,et al.Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer(ToGA):a phase 3,open-label,randomised controlled trial[J].Lancet,2010,376(9742):687-697. 23 Janjigian YY,Kawazoe A,Yaez P,et al.The KEYNOTE-811 trial of dual PD-1 and HER2 blockade in HER2-positive gastric cancer[J].Nature,2021,600(7890):727-730. 24 Shitara K,Iwata H,Takahashi S,et al.Trastuzumab deruxtecan(DS-8201a)in patients with advanced HER2-positive gastric cancer:a dose-expansion,phase 1 study[J].Lancet Oncol,2019,20(6):827-836. 25 Janjigian YY,Oh D-Y,Rha SY,et al.Dose-escalation and dose-expansion study of trastuzumab deruxtecan(T-DXd)monotherapy and combinations in patients(pts)with advanced/metastatic HER2+ gastric cancer(GC)/gastroesophageal junction adenocarcinoma(GEJA):DESTINY-Gastric03[J].J Clin Oncol,2022,40(4_suppl):295. 26 Fukuoka S,Hara H,Takahashi N,et al.Regorafenib plus nivolumab in patients with advanced gastric or colorectal cancer:an open-label,dose-escalation,and dose-expansion phase Ib trial(REGONIVO,EPOC1603)[J].J Clin Oncol,2020,38(18):2053-2061. 27 Nakajima TE,Kadowaki S,Minashi K,et al.Multicenter phase I/II study of nivolumab combined with paclitaxel plus ramucirumab as second-line treatment in patients with advanced gastric cancer[J].Clin Cancer Res,2021,27(4):1029-1036. 28 Geisler AN,Phillips GS,Barrios DM,et al.Immune checkpoint inhibitor-related dermatologic adverse events[J].J Am Acad Dermatol,2020,83(5):1255-1268. 29 CHANG X,GE X,ZHANG Y,et al.The current management and biomarkers of immunotherapy in advanced gastric cancer[J].Medicine(Baltimore),2022,101(21):e29304. 30 Alcantara M,Du Rusquec P,Romano E.Current clinical evidence and potential solutions to increase benefit of CAR T-Cell therapy for patients with solid tumors[J].Oncoimmunology,2020,9(1):1777064. 31 TAO K,HE M,TAO F,et al.Development of NKG2D-based chimeric antigen receptor-T cells for gastric cancer treatment[J].Cancer Chemother Pharmacol,2018,82(5):815-827. 32 LV J,ZHAO R,WU D,et al.Mesothelin is a target of chimeric antigen receptor T cells for treating gastric cancer[J].J Hematol Oncol,2019,12(1):18. 33 QI C,GONG J,LI J,et al.Claudin18.2-specific CAR T cells in gastrointestinal cancers:phase 1 trial interim results[J].Nat Med,2022,28(6):1189-1198. 34 HE J,XIONG X,YANG H,et al.Defined tumor antigen-specific T cells potentiate personalized TCR-T cell therapy and prediction of immunotherapy response[J].Cell Res,2022,32(6):530-542. 35 Fujiwara S,Wada H,Kawada J,et al.NY-ESO-1 antibody as a novel tumour marker of gastric cancer[J].Br J Cancer,2013,108(5):1119-1125. 36 Ishikawa H,Imano M,Shiraishi O,et al.Phase I clinical trial of vaccination with LY6K-derived peptide in patients with advanced gastric cancer[J].Gastric Cancer,2014,17(1):173-180. 37 LIU Q,CHU Y,SHAO J,et al.Benefits of an immunogenic personalized neoantigen nanovaccine in patients with high-risk gastric/gastroesophageal junction cancer[J].Adv Sci(Weinh),2022,10(1):e2203298. |