GATA4对肿瘤影响的研究进展

doi:10.11904/j.issn.1002-3070.2025.04.012

摘要/Abstract

摘要： GATA结合蛋白(GATA binding protein)是一类家族性转录因子,在人体正常生长发育中发挥重要作用。GATA4是GATA家族成员之一,由于GATA4具有调节多种类型肿瘤细胞生物学活性的作用,因此日益受到关注。本文概述了GATA4 在不同类型肿瘤中表达的生物学机制及甲基化修饰对GATA4表达的影响,深入探讨GATA4 与其他信号通路的交互作用,以及对肿瘤微环境的影响,展现其作为肿瘤生物标志物和治疗靶点的巨大潜力,旨在为GATA4在肿瘤发生发展中的作用机制、表观遗传调控的研究提供参考,并为探索GATA4作为肿瘤诊断标志物或靶向治疗新策略的潜在应用奠定理论基础。

关键词: 转录因子, GATA结合蛋白4, 甲基化, 肿瘤, 信号通路

Abstract: GATA binding proteins are a family of transcription factors that play crucial roles in normal human growth and development.GATA4,one of the members of the GATA family,has received increasing attention due to its ability to regulate the biological activities of various types of tumor cells.This article provides an overview of the biological mechanisms of GATA4 expression in different types of tumors and the effects of methylation modifications on GATA4 expression.It further explores the interactions between GATA4 and other signaling pathways,as well as its impact on the tumor microenvironment,demonstrating its enormous potential as tumor biomarker and therapeutic target.The aim is to provide a reference for further research of GATA4′s mechanism of action and epigenetic regulation in the tumor development,to lay a theoretical foundation for exploring the potential application of GATA4 as a tumor diagnostic biomarker or targeted therapy strategy.

Key words: Transcription factors, GATA binding protein 4, Methylation, Tumor, Signaling pathways

中图分类号:

李晓桐, 苗苗, 侯锴炯, 陈红. GATA4对肿瘤影响的研究进展[J]. 实用肿瘤学杂志, 2025, 39(4): 338-342.

LI Xiaotong, MIAO Miao, HOU Kaijiong, CHEN Hong. Research progress in the impact of GATA4 on tumors[J]. Journal of Practical Oncology, 2025, 39(4): 338-342.

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