CDC5L基因与恶性肿瘤的研究进展

doi:10.11904/j.issn.1002-3070.2025.04.016

摘要/Abstract

摘要： 细胞分裂周期5样(cell division cycle 5 like,CDC5L)蛋白是一种由CDC5L基因编码的核蛋白,其表达呈现细胞周期依赖性,在整个细胞周期进程中发挥至关重要的作用。在细胞周期过程中,CDC5L的表达及降解受到严格调控,其异常表达可导致细胞周期失控,干扰细胞的有丝分裂,进而导致细胞染色体的不稳定,最终促进肿瘤的发生。本文以CDC5L结构与功能为切入点,对CDC5L基因在肿瘤中的作用机制及其与预后的关系进行综述。

关键词: 细胞分裂周期5样, 细胞周期, 肿瘤, 恶性表型

Abstract: Cell division cycle 5 like(CDC5L)is a nuclear protein encoded by the CDC5L gene,which exhibits cell cycle-dependent expression and plays a critical role throughout the cell cycle process.The expression and degradation of CDC5L in the cell cycle process are strictly regulated.Its expression disorder can cause the cell cycle to run out of control,interfere with the mitosis of cells,and then cause the instability of cell chromosomes,which ultimately promotes the occurrence of tumors.This review focuses on the structure and function of CDC5L,summarizing the mechanisms of the CDC5L gene in tumorigenesis and its relationship with prognosis.

Key words: Cell division cycle 5 like, Cell cycle, Tumor, Malignant phenotype

中图分类号:

R730.7

梁晓丹, 国昊楠. CDC5L基因与恶性肿瘤的研究进展[J]. 实用肿瘤学杂志, 2025, 39(4): 358-362.

LIANG Xiaodan, GUO Haonan. Research advances on the CDC5L gene in malignant tumors[J]. Journal of Practical Oncology, 2025, 39(4): 358-362.

参考文献

1 Zhou RH,Zhang JT,Chen C,et al.Identification of CDC5L as bridge gene between chronic obstructive pulmonary disease and lung adenocarcinoma[J].Epigenomics,2020,12(17):1515-1529.
2 Li J,Zhang N,Zhang R,et al.CDC5L promotes hTERT expression and colorectal tumor growth[J].Cell Physiol Biochem,2017,41(6):2475-2488.
3 Zhang C,Li Y,Zhao W,et al.Circ-PGAM1 promotes malignant progression of epithelial ovarian cancer through regulation of the miR-542-3p/CDC5L/PEAK1 pathway[J].Cancer Med,2020,9(10):3500-3521.
4 Ohi R,Feoktistova A,Mccann S,et al.Myb-related schizosaccharomyces pombe cdc5p is structurally and functionally conserved in eukaryotes[J].Mol Cell Biol,1998,18(7):4097-4108.
5 Bernstein HS,Coughlin SR.Pombe Cdc5-related protein.A putative human transcription factor implicated in mitogen-activated signaling[J].J Biol Chem,1997,272(9):5833-5837.
6 Botchkarev VV,Haber JE.Functions and regulation of the polo-like kinase Cdc5 in the absence and presence of DNA damage[J].Curr Genet,2018,64(1):87-96.
7 Bernstein HS,Coughlin SR.A mammalian homolog of fission yeast Cdc5 regulates G2 progression and mitotic entry[J].J Biol Chem,1998,273(8):4666-4671.
8 Jokoji G,Maeda S,Oishi K,et al.CDC5L promotes early chondrocyte differentiation and proliferation by modulating pre-mRNA splicing of SOX9,COL2A1,and WEE1[J].J Biol Chem,2021,297(2):100994.
9 穆蕊.CDC5L在细胞有丝分裂期的功能研究[D].北京:中国人民解放军军事医学科学院,2011.
10 Mu R,Wang YB,Wu M,et al.Depletion of pre-mRNA splicing factor CDC5L inhibits mitotic progression and triggers mitotic catastrophe[J].Cell Death Dis,2014,5(3):e1151.
11 Bray F,Laversanne M,Sung H,et al.Global cancer statistics 2022:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J].CA Cancer J Clin,2024,74(3):229-263.
12 Yu N,Wu Y,Wei Q,et al.m6A modification of CDC5L promotes lung adenocarcinoma progression through transcriptionally regulating WNT7B expression[J].Am J Cancer Res,2024,14(7):3565-3583.
13 Chen G,Wei RS,Ma J,et al.FOXA1 prolongs S phase and promotes cancer progression in non-small cell lung cancer through upregulation of CDC5L and activation of the ERK1/2 and JAK2 pathways[J].Kaohsiung J Med Sci,2023,39(11):1077-1086.
14 Meng X,Lou QY,Yang WY,et al.The role of non-coding RNAs in drug resistance of oral squamous cell carcinoma and therapeutic potential[J].Cancer Commun(Lond),2021,41(10):981-1006.
15 贾文仙,蒋敏,刘佳艺,等.CDC5L蛋白在口腔鳞状细胞癌中的表达及临床意义[J].广西医科大学学报,2020,37(06):1084-1088.
16 肖又德,郑永法,戈伟.加权基因共表达网络分析筛胃癌相关分子[J].中国医药导报,2021,18(17):8-12,24,197.
17 Zhu H,Tang JH,Zhang SM,et al.Long noncoding RNA LINC00963 promotes CDC5L-mediated malignant progression in gastric cancer[J].Onco Targets Ther,2020,13:12999-13013.
18 Cui J,Cao N,Wang G,et al.HuR promotes the progression of gastric cancer through mediating CDC5L expression[J].Dis Markers,2022,2022:5141927.
19 Smaglo BG.Role for neoadjuvant systemic therapy for potentially resectable pancreatic cancer[J].Cancers(Basel),2023,15(8):2377.
20 Chen J,Zhao CC,Chen FR,et al.KIF4A regulates the progression of pancreatic ductal adenocarcinoma through proliferation and invasion[J].Biomed Res Int,2021,2021:8249293.
21 Qiu H,Zhang X,Ni W,et al.Expression and clinical role of CDC5L as a novel cell cycle protein in hepatocellular carcinoma[J].Dig Dis Sci,2016,61(3):795-805.
22 Huang R,Xue R,Qu D,et al.Prp19 arrests cell cycle via CDC5L in hepatocellular carcinoma cells[J].Int J Mol Sci,2017,18(4):778.
23 刘云,高登鹏,徐亚飞,等.结直肠癌组织中CDC5L、DDX21及端粒酶的表达与临床意义 [J].西部医学,2023,35(3):348-353.
24 Zhang Z,Mao W,Wang L,et al.Depletion of CDC5L inhibits bladder cancer tumorigenesis[J].J Cancer,2020,11(2):353-363.
25 王雪,张广美,何征秦.复发性卵巢癌的药物治疗及进展[J].中国现代医学杂志,2021,31(1):38-44.
26 董海燕,庞晓燕,窦磊,等.细胞周期蛋白E1基因在卵巢癌诊治中的作用[J].中国现代医学杂志,2021,31(1):33-37.
27 Zheng M,Long J,Chelariu-Raicu A,et al.Identification of a novel tumor microenvironment prognostic signature for advanced-stage serous ovarian cancer[J].Cancers(Basel),2021,13(13):3343.
28 Li X,Wang X,Song W,et al.Oncogenic properties of NEAT1 in prostate cancer cells depend on the CDC5L-agrn transcriptional regulation circuit[J].Cancer Res,2018,78(15):4138-4149.
29 蔡元霞,武志祥,王奕,等.CDC5L表达对神经母细胞瘤临床及预后评估的意义[J].临床小儿外科杂志,2019,18(6):472-479.
30 Liu H,Guo D,Sha Y,et al.ANXA7 promotes the cell cycle,proliferation and cell adhesion-mediated drug resistance of multiple myeloma cells by up-regulating CDC5L[J].Aging(Albany NY),2020,12(11):11100-11115.
31 Xu J,Wang Y,Ren L,et al.IGF2BP1 promotes multiple myeloma with chromosome 1q gain via increasing CDC5L expression in an m6A-dependent manner[J].Genes Dis,2025,12(1):101214.
32 Smrke A,Anderson PM,Gulia A,et al.Future directions in the treatment of osteosarcoma[J].Cells,2021,10(1):172.
33 Mohammadi M,Goudarzi PK,Rahmani O,et al.Evaluation of gene expression level of CDC5L and MACC1 in poor prognosis and progression of osteosarcoma[J].Tumour Biol,2016,37(6):8153-8157.
34 Lu XY,Lu Y,Zhao YJ,et al.Cell cycle regulator gene CDC5L,a potential target for 6p12-p21 amplicon in osteosarcoma[J].Mol Cancer Res,2008,6(6):937-946.
35 Gu Z,Zhang H,Li Y,et al.CDC5L drives FAH expression to promote metabolic reprogramming in melanoma[J].Oncotarget,2017,8(69):114328-114343.

[1]	穆慧娟, 礼彦侠, 马祥, 祝天岑, 那军, 阎涵, 邢立莹. 辽宁省肿瘤登记工作40年发展历程与展望[J]. 实用肿瘤学杂志, 2025, 39(4): 267-271.
[2]	马东琼, 杨沧江, 朱云芳, 文洪梅, 曹继东, 戴堂艳, 雷国艳, 李冬克, 石青萍. 2020年云南省肿瘤登记地区女性乳腺癌发病和死亡情况及2012—2020年趋势分析[J]. 实用肿瘤学杂志, 2025, 39(4): 272-277.
[3]	代晓泽, 马玉霞, 李雨婷, 齐笑晴, 祝天岑, 穆慧娟, 刘辉. 2014—2020年辽宁省阜新市城市居民恶性肿瘤发病与死亡流行趋势分析[J]. 实用肿瘤学杂志, 2025, 39(4): 278-283.
[4]	付宏晨, 成会荣, 唐娴, 文洪梅, 陈杨, 石青萍, 任思颖, 朱云芳, 伍福仙. 2020年云南省肿瘤登记地区结直肠癌发病和死亡情况及2012—2020年趋势分析[J]. 实用肿瘤学杂志, 2025, 39(4): 288-293.
[5]	祝天岑, 礼彦侠, 任方晗, 代晓泽, 刘洋, 穆慧娟. 2021年辽宁省肿瘤登记地区恶性肿瘤流行情况分析[J]. 实用肿瘤学杂志, 2025, 39(4): 294-300.
[6]	李晓桐, 苗苗, 侯锴炯, 陈红. GATA4对肿瘤影响的研究进展[J]. 实用肿瘤学杂志, 2025, 39(4): 338-342.
[7]	曹晶晶, 张弓. 肿瘤治疗电场在胶质母细胞瘤治疗中的应用进展[J]. 实用肿瘤学杂志, 2025, 39(4): 353-357.
[8]	李吉, 张茂镕, 杨昭, 文洪梅, 伍福仙, 李云涛. 2020年云南省昆明市肿瘤登记地区恶性肿瘤发病和死亡特征及2016—2020年趋势分析[J]. 实用肿瘤学杂志, 2025, 39(3): 169-176.
[9]	李冬生, 李泽昊, 陈永刚. 铁死亡相关基因的DNA甲基化风险评分模型在结肠癌预后与免疫特征评估中的应用[J]. 实用肿瘤学杂志, 2025, 39(3): 224-234.
[10]	叶倩妮, 李娟, 王发琳, 刘家仁. 植物化学物在肿瘤微环境中的作用研究进展[J]. 实用肿瘤学杂志, 2025, 39(3): 245-250.
[11]	武旭, 德乐黑巴特尔, 达林泰, 苏尼特, 刘军. 长链非编码RNA在口腔鳞状细胞癌中的研究进展[J]. 实用肿瘤学杂志, 2025, 39(3): 251-255.
[12]	吴宜伟, 韩静, 颜雪, 王文瑞. 内蒙古自治区2010—2020年头颈部肿瘤死亡趋势分析[J]. 实用肿瘤学杂志, 2025, 39(2): 86-90.
[13]	陈丽娟, 马欣欣, 高光强, 田虹, 刘家仁. 二氢猕猴桃内酯抑制胃癌细胞增殖的作用机制研究[J]. 实用肿瘤学杂志, 2025, 39(2): 91-98.
[14]	文小焱, 陈俐. 2010年和2020年四川省30岁及以上人群恶性肿瘤疾病负担比较分析[J]. 实用肿瘤学杂志, 2025, 39(1): 1-6.
[15]	李群, 石汉平, 杨柳青. 肿瘤患者的营养治疗[J]. 实用肿瘤学杂志, 2024, 38(6): 417-420.