CD44V6、E-cadherin与非小细胞肺癌骨、脑转移关系的研究

doi:10.3969/j.issn.1002-3070.2009.02.003

实用肿瘤学杂志 ›› 2009, Vol. 23 ›› Issue (2): 110-112.doi: 10.3969/j.issn.1002-3070.2009.02.003

CD44V6、E-cadherin与非小细胞肺癌骨、脑转移关系的研究

赵春波¹,吕丽艳²

1.哈尔滨医科大学附属肿瘤医院(哈尔滨 150081);
2.哈尔滨医科大学附属第一医院肿瘤科

收稿日期:2008-10-27 出版日期:2009-04-20 发布日期:2012-02-21
作者简介:赵春波,男,(1978-),硕士研究生,住院医生,从事肿瘤放射治疗基础和临床研究

Expression and significanc of E-cadherin and CD44V6 in the metastasis of bone and brain of NSCLC

ZHAO Chunbo¹,LV Liyan²

1.Department of Radiation Oncology,The Affiliated Tumor Hospital of Harbin Medical University,Harbin 150081
2.Department of Radiation Oncology,The First Hospital Affiliated Harbin Medical University,Harbin 150001

Received:2008-10-27 Online:2009-04-20 Published:2012-02-21

摘要/Abstract

摘要： 目的探讨非小细胞肺癌(NSCLC)及癌旁组织中CD44V6和上皮钙依赖黏附蛋白(E-cadherin、E-cad)的表达与NSCLC发生骨、脑转移的关系。方法采用免疫组化Envision法检测65例NSCLC组织及30例癌旁组织中CD44V6和E-cad的表达情况,分析与NSCLC骨、脑转移的关系。结果 NSCLC原发病灶组织中CD44V6阳性表达率44.6%(29/65),在癌旁组织中无表达,且与NSCLC组织分型、TNM分期及骨、脑转移呈正相关(P＜0.05),E-cad阳性表达率53.8%(35/65),显著低于癌旁组织(80%)(P﹤0.05),且与NSCLC分化程度、TNM分期及骨、脑转移呈负相关(P＜0.05)。结论对NSCLC进行CD44V6及E-cad的检测,有助于预测NSCLC骨、脑转移倾向和评估NSCLC患者的预后。

Abstract: Objective To explore the significance of the expression of E-cad and CD44V6 in the metastasis of bone and brain of NSCLC.Methods The expression of E-cad and CD44V6 in 65 specimens of NSCLC and 30 specimens of adjacent normal tissues were detected by Envision immunohistochemistry.Result the high expression rate of CD44V6 was 44.6% in NSCLC,and 0 in adjacent normal tissues.CD44V6 staining in NSCLC tissues was correlated to classification,bone and brain metastasis and TNM stage(P＜0.05).The high expression rate of E-cad was significantly lower in NSCLC than that in adjacent normal tissues(53.8%vs.80.0%,P＜0.05).E-cad staining in NSCLC tissues was correlated to differentiation,bone and brain metastasis and TNM stage(P＜0.05).Conclusion Determination of CD44V6 and E-cad by immunohistchemistry might be useful in assessing tumor progression and distant metastasis and in predicting prognosis of lung cancer.

中图分类号:

R730.231⁺³

赵春波,吕丽艳. CD44V6、E-cadherin与非小细胞肺癌骨、脑转移关系的研究[J]. 实用肿瘤学杂志, 2009, 23(2): 110-112.

ZHAO Chunbo,LV Liyan. Expression and significanc of E-cadherin and CD44V6 in the metastasis of bone and brain of NSCLC[J]. PRACTICAL ONCOLOGY JOURNAL, 2009, 23(2): 110-112.

CD44V6、E-cadherin与非小细胞肺癌骨、脑转移关系的研究

Expression and significanc of E-cadherin and CD44V6 in the metastasis of bone and brain of NSCLC

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