实用肿瘤学杂志 ›› 2009, Vol. 23 ›› Issue (3): 233-234.doi: 10.3969/j.issn.1002-3070.2009.03.010

• 论著 • 上一篇    下一篇

替勃龙在宫颈鳞癌患者中的应用分析

刘运铎, 娄阁   

  1. 哈尔滨医科大学附属肿瘤医院(哈尔滨 150081)
  • 收稿日期:2009-03-23 出版日期:2009-03-25 发布日期:2012-02-21
  • 作者简介:刘运铎, 女, (1981-), 住院医师, 从事妇科肿瘤的诊治研究

The clinical application of Tibolone in patients of cervical squamous cell cancer

LIU Yunduo, LOU Ge   

  1. The Affiliated Tumor Hospital of Harbin Medical University, Harbin 150081
  • Received:2009-03-23 Online:2009-03-25 Published:2012-02-21

摘要: 目的观察性激素替勃龙在宫颈鳞癌术后患者中的应用效果。方法 采用放免法检测替勃龙组及安慰剂对照组患者性激素六项水平, 生化仪检测血中总胆固醇(TC)、甘油三酯(TG)含量, QCT骨密度仪测量第三腰椎骨密度(BMD), SCL-90症状自评量表问卷法测定宫颈癌患者的生存质量。 结果 替勃龙组E2及BMD较安慰剂组显著升高, 而FSH、LH、TC、TG较安慰剂组显著降低。结论 替勃龙能有效改善宫颈鳞癌术后患者绝经期症状, 提高生存质量。

关键词: 替勃龙, 宫颈鳞癌, 激素替代疗法

Abstract: Objective To observe the application of Tibolone in patients of cervical squamous cell cancer.Methods The levels of six reproductive hormone were evaluated by RI.The levels of TC and TG were determined by automatic biochemistry analyzer.The bone mineral density of lumbar vertebra was measured by QCT.The QOL was evaluated by 90 self-rating symptom table.Results Compared with placebo, the levels of E2 and BMD were significant higher in the group of Tibolone, but the levels of FSH, LH, TC and TG were low.Conclusion Tibolone improves climacteric syndrome efficiently in post-operative patients of cervical squamous cell cancer and the QOL.

Key words: Tibolone, Cervical squamous cell cancer, HRT

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