Abstract: Objective To discuss the effect of Shenqi Fuzheng injection(SQFZI)on hyperthermic intraperitoneal lavage chemotherapy for gastric cancer.Methods Sixty gastric cancer patients were assigned to two groups randomly, the control group treated with hyperthermic intraperitoneal lavage chemotherapy alone and the treated group treated with SQFZI combined with hyperthermic intraperitoneal lavage chemotherapy.To observe incidence rate of untoward reaction and the cases of stoping hyperthermic intraperitoneal lavage chemotherapy.To detect the changing of WBC, Hb, PLT and subsets of lymphocytes(CD4, CD8, CD4/CD8)in peripheral lymphocytes counts before and after treatment.Results Incidence rate of untoward reaction and the cases of stoping hyperthermic intraperitoneal lavage chemotherapy in treated group were significantly lower than that in control group(P ＜ 0.05).There were statistical differences between treated group and control group.The descent of WBC in treated group were significantly lower than that in control group(P ＜ 0.05).There were statistical differences between treated group and control group.The percentage of CD4 and the number of CD4/CD8 in treated group were significantly higher than that in control group(P ＜ 0.05).There were statistical differences between treated group and control group.Conclusions SQFZI could effectively improve the immune function, prevent the descent of WBC of gastric carcinoma patient treated with hyperthermic intraperitoneal lavage chemotherapy, help gastric carcinoma patient to finish their treatment, raise patients′quality of life.