乳腺癌患者血清肿瘤标志物与免疫组化标志物相关性的研究

doi:10.3969/j.issn.1002-3070.2010.03.007

实用肿瘤学杂志 ›› 2010, Vol. 24 ›› Issue (3): 224-226.doi: 10.3969/j.issn.1002-3070.2010.03.007

乳腺癌患者血清肿瘤标志物与免疫组化标志物相关性的研究

仲崇明¹, 周彦¹, 卞光荣¹, 孙志超², 贾惠英², 鲁凯³, 姚壮凯³

1.连云港市第二人民医院检验科(连云港 222023);
2.连云港市第二人民医院病理科;
3.连云港市第二人民医院普外科

收稿日期:2010-04-07 出版日期:2010-06-28 发布日期:2015-01-24
通讯作者: 仲崇明,E-mail:chongmingzhong@126.com
作者简介:仲崇明,男,(1964-),本科,副主任技师,从事免疫学检验研究

Correlation between serum tumor marker and immumohistochemical marker in breast cancer

ZHONG Chongming¹, ZHOU Yan¹, BIAN Guangrong¹, SUN Zhichao², JIA Huiying², LU Kai³, YAO Zhuangkai³

1.Department of Clinical Laboratory;
2.Department of Pathology;
3.Department of General Surgery,The Second People′s Hospital of Lianyungang,Lianyungang 222023

Received:2010-04-07 Online:2010-06-28 Published:2015-01-24

摘要/Abstract

摘要： 目的探讨乳腺癌患者血清肿瘤标志物(TM)糖类抗原15-3(CA15-3)、癌胚抗原(CEA)与免疫组化标志物C-erbB2、雌激素受体(ER)、孕激素受体(PR)的关联性。方法对65例乳腺癌患者术前采用电化学发光法检测血清CA15-3和CEA,术后组织标本免疫组织化学染色检测C-erbB2、ER、PR,分析CA15-3、CEA与C-erbB2、ER、PR的相关性。结果 CA15-3与C-erbB2相关系数r=0.597(P=0.000),与ER相关系数r=-0.190(P=0.129),与PR相关系数r=-0.179(P=0.153);CEA与C-erbB2相关系数r=0.414(P=0.001),与ER相关系数r=-0.267(P=0.031),与PR相关系数r=-0.157(P=0.211);随临床分期程度增加,CA15-3、CEA、C-erbB2阳性率有升高的趋势,(P值分别为0.077、0.772、0.038)。结论 CA15-3与C-erbB2正相关,CEA与C-erbB2正相关、与ER负相关;随着临床分期的增加,C-erbB2阳性率显著增加,CA15-3、CEA阳性率存在增加的趋势。

Abstract: Objective To study the correlation between serum tumor marker and immumohistochemical marker of breast cancer.Methods To determine CA15-3 and CEA in serum of 65 breast cancer before surgery by electro chemiluminescent immunoassay(ECLIA).The expressions of C-erbB2,ER,PR in 65 breast cancer tissues were detected by immunohistochemistry,and analyze the correlation of them.Results CA15-3 was positively correlated with C-erbB2(r=0.597,P=0.000),negatively correlated but no significant with ER(r=-0.190,P=0.129),and PR(r=-0.179,P=0.153);CEA was positively correlated with C-erbB2(r=0.414,P=0.001),negatively correlated with ER(r=-0.267,P=0.031),negatively correlated but no significant with PR(r=-0.157,P=0.211);The positive rate of C-erbB2 in breast cancer was increased significantly with the clinical stage increasing(P=0.038),the positive rate of CA15-3 and CEA were increased with the clinical stage increasing(P=0.077,P=0.772).Conclusions CA15-3 was positively correlated with C-erbB2.CEA was positively correlated with C-erbB2,negatively correlated with ER;the positively rate of C-erbB2 in breast cancer was increased significantly with the clinical stage increasing,the positive rate of CA15-3 and CEA were increased with the clinical stage increasing.

中图分类号:

R737.9

仲崇明, 周彦, 卞光荣, 孙志超, 贾惠英, 鲁凯, 姚壮凯. 乳腺癌患者血清肿瘤标志物与免疫组化标志物相关性的研究[J]. 实用肿瘤学杂志, 2010, 24(3): 224-226.

ZHONG Chongming, ZHOU Yan, BIAN Guangrong, SUN Zhichao, JIA Huiying, LU Kai, YAO Zhuangkai. Correlation between serum tumor marker and immumohistochemical marker in breast cancer[J]. PRACTICAL ONCOLOGY JOURNAL, 2010, 24(3): 224-226.

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乳腺癌患者血清肿瘤标志物与免疫组化标志物相关性的研究

Correlation between serum tumor marker and immumohistochemical marker in breast cancer

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