实用肿瘤学杂志 ›› 2011, Vol. 25 ›› Issue (5): 437-438.doi: 10.3969/j.issn.1002-3070.2011.05.008

• 论著 • 上一篇    下一篇

紫杉醇周疗同步放疗治疗复发转移乳腺癌

莫雪莉, 王德林, 曹玉娟, 杜芳, 曹凤, 孙建华, 刘承伟, 郝龙英   

  1. 北京大学首钢医院肿瘤科(北京 100144)
  • 收稿日期:2011-05-25 出版日期:2011-10-28 发布日期:2014-12-02
  • 通讯作者: 莫雪莉,E-mail:xuelimo@hotmail.com
  • 作者简介:莫雪莉,女,(1968-),本科,主治医师,从事肿瘤的内科研究

Concurrent chemoradiotherapy with weekly Paclitaxol in advanced breast cancer

MO Xueli,WANG Delin,CAO Yujuan,DU Fang,CAO Feng,SUN Jianhua,LIU Chengwei,HAO Longying   

  1. Department of Medical Oncology,Peking University Shougang Hospital,Beijing 100144
  • Received:2011-05-25 Online:2011-10-28 Published:2014-12-02

摘要: 目的 探讨伴有压迫症状的脑转移或骨转移且合并内脏转移的晚期乳腺癌合理的治疗模式。方法 化疗方案均为单药紫杉醇80 mg/m2 d1,d8、d15,21天为1周期。全脑放疗采用高能X线全脑对穿照射,总量分别为45 Gy和40 Gy。骨放疗采用X线外照射,总量分别为33 Gy和40 Gy。放化疗同步进行。临床疗效评定按WHO实体瘤疗效评定标准。每完成2个周期化疗进行一次疗效评价。结果 4例患者总体疗效评价均为PR,神经系统压迫症状及骨痛症状均得到缓解,TTP分别为9个月、5个月、6+个月和8.5个月。结论 采用同步放化疗治疗有压迫症状的脑转移或骨转移且合并内脏转移的晚期乳腺癌,可以有效缓解症状、改善生存质量。

关键词: 晚期乳腺癌, 同步治疗, 化疗, 放疗

Abstract: Objective To investigate the treatment pattern in patients with visceral organ metastatic breast cancer who having symptoms of brain or bone metastasis involved.Method The total dose of whole-brain radiotherapy were 45Gy and 40Gy,respectively.Ther bone radiotherapy were 33Gy and 40Gy,respectively.At the same time,chemotherapy were given with Paclitaxol 80mg/m2,d1、8、15,every 21 days as one cycle.The efficacy was evaluated every 2 cycles of chemotherapy according to WHO standard.Result The Objective efficacy of 4 patients were PR.The constricts symptoms of the CNS and pain of the bone were relieved.TTP of 4 patients were 9、5、6+ and 8.5 months,respectively. Conclusion Treatment pattern of concurrent chemoradiotherapy in visceral organ metastatic patients with having symptoms of brain or bone metastasis result in a effectiveness to reduce symptoms and improve QOL.

Key words: Advanced breast cancer, Concurrent chemoradiotherapy, Chemotherapy, Radiotherapy

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