实用肿瘤学杂志 ›› 2011, Vol. 25 ›› Issue (6): 568-570.doi: 10.3969/j.issn.1002-3070.2011.06.018

• 综述 • 上一篇    下一篇

高迁移率族蛋白B1促肿瘤转移

肖建彪1, 陈斌2, 陈龙华1   

  1. 1.南方医科大学南方医院放疗科(广州 510515);
    2.广州军区广州总医院肿瘤科
  • 收稿日期:2011-08-15 出版日期:2011-12-28 发布日期:2014-12-02
  • 通讯作者: 陈龙华,E-mail:flkx2010@163.com
  • 作者简介:肖建彪,男,(1983-),在读硕士研究生,从事肿瘤学研究
  • 基金资助:
    国家自然科学基金青年科学基金(81101822);广州市科技计划重点项目(11C26090521);广东省自然科学基金(10451001002005047)

Role of High Mobibity Group Box 1 protein enhancing tumor metastasis

XIAO Jianbiao1,CHEN Bin2,CHEN Longhua1   

  1. 1.Departmant of Radiation,Nanfang Hospital Southen Medical University,Guangzhou 510515;Depertment of Oncology;Guangzhou General Hospital of Guangzhou Military Region,Guangzhou 510010
  • Received:2011-08-15 Online:2011-12-28 Published:2014-12-02

摘要: 高迁移率族蛋白B1(HMGB1)是存在于真核细胞生物体内的一类非组蛋白染色体结合蛋白,HMGB1通过刺激肿瘤细胞增殖、抑制其凋亡,增强细胞移动性,提高纤溶酶原活性,促进淋巴管和血管生成等促进肿瘤转移。HMGB1在多种晚期肿瘤中高表达,是一种重要的促肿瘤转移因子。

Abstract: High mobility group box1(HMGB1)protein as a group of nonhistone chromosomal protein in the nuclear of eukaryote cell.HMGB1 promotes Neoplasm Metastasis by stimulating cell proliferation and inhibition apoptosis of Neoplasm cells,strengthening cell migration,enhancing activation of plasminogen,boosting lymphatic and blood vessel formation.HMGB1 has been over expressed by a lot of advanced cancers,and it is an important promoting neoplasm metastasis factor.

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