实用肿瘤学杂志 ›› 2012, Vol. 26 ›› Issue (2): 188-192.doi: 10.3969/j.issn.1002-3070.2012.02.020

• 综述 • 上一篇    

Ki-67在乳腺癌新辅助化疗中的作用及临床意义

滕冲, 宋晓薇, 蔡莉   

  1. 哈尔滨医科大学附属第三医院内科(哈尔滨 150081)
  • 收稿日期:2011-12-09 出版日期:2012-04-28 发布日期:2014-12-03
  • 通讯作者: 蔡莉,E-mail:caiwenxin76@yahoo.com.cn
  • 作者简介:滕冲,女,(1986-),硕士研究生,从事肿瘤内科研究

Effect and clinical significance of Ki-67 in neoadjuvant chemotherapy for breast cancer

TENG Chong,SONG Xiaowei,CAI Li   

  1. Department of Internal Medicine,The Third Affiliated Hospital of Harbin Medical University,Harbin 150081
  • Received:2011-12-09 Online:2012-04-28 Published:2014-12-03

摘要: 新辅助化疗主要应用于局部晚期乳腺癌的治疗,疗效评价常用的指标为临床上缓解和病理学上缓解的程度。Ki-67是与细胞分裂增殖有关的核蛋白,已广泛应用于各种肿瘤的诊断及预后。多项临床研究资料表明Ki-67在判断乳腺癌新辅助化疗是否有效中显示出潜在的价值,现就Ki-67在乳腺癌新辅助化疗中的作用及临床意义作一综述。

Abstract: Neoadjuvant chemotherapy(NAC)is one of the main strategies for patients with locally advanced breast cancer.Clinical and pathologic response rates are equivalent used for evaluating therapeutic effect.The expression of Ki-67 protein is associated with cell proliferation.It has been widely used in the diagnosis and prognosis of various tumors.A number of clinical data indicate that Ki-67 demonstrated a potential value in determining the effectiveness of neoadjuvant chemotherapy for breast cancer.The role of Ki-67 on neoadjurant chemotherapy and its clinical significance is reviewed.

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