实用肿瘤学杂志 ›› 2010, Vol. 24 ›› Issue (4): 332-336.doi: 10.3969/j.issn.1002-3070.2010.04.010

• 论著 • 上一篇    下一篇

乳腺癌术后放疗引起放射性肺损伤的临床分析

王顺, 张大水, 刘沙, 王明坤, 潘涛   

  1. 海南医学院附属医院放疗科(海口 570102)
  • 收稿日期:2010-07-21 出版日期:2010-08-28 发布日期:2015-01-24
  • 通讯作者: 王顺,E-mail:liushakk@qq.com
  • 作者简介:王顺 医学博士,主任医师,教授,硕士研究生导师。海南医学院肿瘤研究所副主任,海南医学院附属医院放射肿瘤科主任。国家自然基金放射肿瘤和放射生物专业评委,海南省放射肿瘤专业委员会副主任委员,海南省抗癌协会常务理事,海南省抗癌协会乳腺癌专业委员会常委。海南医学院附属医院保乳微创治疗组核心成员,主持和参与国家和省部级课题多项,“染色体辐射损伤与放射敏感性”、“肿瘤放射敏感性与DNA修复基因变异和多态性关系”系列研究获上海市科技奖。

Clinical analysis on postoperative radiation induced lung injury in patient with breast cancer

WANG Shun, ZHANG Dashui, LIU Sha, WANG Mingkun, PAN Tao   

  1. Department of Radiation Oncology,The Affiliated Hospital of Hainan Medical College,Haikou 570102
  • Received:2010-07-21 Online:2010-08-28 Published:2015-01-24

摘要: 目的 分析乳腺癌术后放疗引起放射性肺损伤的临床相关因素,为优化放疗计划提供参考。方法 对96例术后放疗的乳腺癌患者进行回顾性分析,观察手术方式,术后放疗的照射野、照射剂量,辅助化疗的种类、年龄、肺部原有基础疾病与放射性肺损伤发生率的关系。结果 96例乳腺癌患者中发生放射性肺损伤19例,放射性肺损伤的发生与照射野、照射剂量有关(P<0.05)。结论 术后放疗照射野的设计和放疗剂量的增加是放射性肺损伤发生率增高的主要因素。

Abstract: Objective To investigate the clinical factors on postoperative radiation induced lung injury in patients with breast cancer,in order to optimize the radiotherapy plan.Method 96 patients with breast cancer who had received postoperative radiotherapy were analyzed,the relationship between the incidence of radiation injury and radiation field,radiation dose,chemotherapy drugs,age,underlying disease of the lung were observed.Results 19 patients developed radiation induced lung injury.The incidence of radiation induced lung injury were related with radiation field,radiation dose(P<0.05).Conclusion The design of radiation field and increasing radiation dose are the major factors to increasing incidence of radiation induced lung injury in patients with breast cancer.

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