维甲酸诱导蛋白在消化系统恶性肿瘤中的研究进展

doi:10.11904/j.issn.1002-3070.2023.06.008

实用肿瘤学杂志 ›› 2023, Vol. 37 ›› Issue (6): 502-506.doi: 10.11904/j.issn.1002-3070.2023.06.008

维甲酸诱导蛋白在消化系统恶性肿瘤中的研究进展

程锦^1,2 综述, 王玮² 审校

1.武汉科技大学医学院(武汉 430065);
2.湖北文理学院附属医院,襄阳市中心医院消化内科

收稿日期:2022-10-26 修回日期:2023-07-12 出版日期:2023-12-28 发布日期:2024-03-18
通讯作者: 王玮,E-mail:32857107@qq.com
作者简介:程锦,女,(1997-),硕士研究生,从事胃癌发病机制相关的研究。
基金资助:
湖北省教育厅科研计划指导性项目(编号:B2020139)

Research progress on retinoic acid-induced proteins in malignant tumors of the digestive system

CHENG Jin^1,2, WANG Wei²

1. College of Medicine,Wuhan University of Science and Technology,Wuhan 430065,China;
2. Department of Gastroenterology,Xiangyang Central Hospital,Affiliated Hospital of Hubei University of Arts and Science

Received:2022-10-26 Revised:2023-07-12 Online:2023-12-28 Published:2024-03-18

摘要/Abstract

摘要： 2020年全球癌症统计报告显示,消化系统恶性肿瘤发病率与死亡率均较高,但消化系统恶性肿瘤发生发展机制仍然未明确。维甲酸诱导蛋白(Retinoic acid-induced protein,RAI)是一类由维甲酸诱导的蛋白,与消化系统恶性肿瘤的增殖、侵袭、迁移关系密切,RAI系列蛋白在消化系统肿瘤中的表达水平与临床预后相关,过表达或敲低RAI蛋白可以影响消化系统恶性肿瘤对于靶向药物治疗的敏感性,RAI蛋白可能是消化系统肿瘤发生发展密切相关的特异性靶蛋白。本文就RAI蛋白在消化系统恶性肿瘤发生发展中的作用及相关机制等进行综述,为疾病早期诊断、治疗及预后评估提供一定的参考。

关键词: 维甲酸诱导蛋白, 消化系统恶性肿瘤

Abstract: The Global Cancer Statistics Report in 2020 shows that the incidence and mortality of digestive system malignancies are high,but the mechanism is still unclear in the occurrence and development of digestive system malignancies.Retinoic acid-induced protein(RAI)is a kind of protein induced by retinoic acid,which is closely related to the proliferation,invasion and migration of digestive system malignant tumors.The expression of RAI series proteins in digestive system tumors is related to clinical prognosis.Overexpression or knockdown of RAI protein can affect the sensitivity of digestive system malignant tumors to targeted drug therapy.RAI protein may also be a specific target protein closely related to the occurrence and development of digestive system tumors.This article reviews the role and related mechanisms of RAI protein in the occurrence and development of malignant tumors in the digestive system,providing some references for early diagnosis,treatment and prognosis assessment of the disease.

Key words: Retinoic acid-induced protein, Malignant tumors of the digestive system

中图分类号:

R735

程锦, 王玮. 维甲酸诱导蛋白在消化系统恶性肿瘤中的研究进展[J]. 实用肿瘤学杂志, 2023, 37(6): 502-506.

CHENG Jin, WANG Wei. Research progress on retinoic acid-induced proteins in malignant tumors of the digestive system[J]. Journal of Practical Oncology, 2023, 37(6): 502-506.

0
/ / 推荐

导出引用管理器 EndNote|Reference Manager|ProCite|BibTeX|RefWorks

链接本文: http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/10.11904/j.issn.1002-3070.2023.06.008

http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/Y2023/V37/I6/502

参考文献

1 Sung H,Ferlay J,Siegel RL,et al.Global cancer statistics 2020:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J].CA Cancer J Clin,2021,71(3):209-249.
2 Bray F,Laversanne M,Weiderpass E,et al.The ever-increasing importance of cancer as a leading cause of premature death worldwide[J].Cancer,2021,127(16):3029-3030.
3 邓婧,王阁,杨进,等.Tec激酶区作用蛋白RAI16的筛选和结构功能分析[J].第三军医大学学报,2006,(2):133-135.
4 Iglesias González PA,Valdivieso AG,Santa-Coloma TA.The G protein-coupled receptor GPRC5A-a phorbol ester and retinoic acid-induced orphan receptor with roles in cancer,inflammation,and immunity[J].Biochem Cell Biol,2023,101(6):465-480.
5 Chen P,Li S,Zhang K,et al.N(6)-methyladenosine demethylase ALKBH5 suppresses malignancy of esophageal cancer by regulating microRNA biogenesis and RAI1 expression[J].Oncogene,2021,40(37):5600-5612.
6 Lang A,Goradia N,Wikman H,et al.(1)H,(13)C,and(15)N backbone assignments of the C-terminal region of the human retinoic acid-induced protein 2[J].Biomol NMR Assign,2020,14(2):271-275.
7 Cheng L,Yang S,Yang Y,et al.Global gene expression and functional network analysis of gastric cancer identify extended pathway maps and GPRC5A as a potential biomarker[J].Cancer Lett,2012,326(1):105-113.
8 Kutty RK,Chen S,Samuel W,et al.Cell density-dependent nuclear/cytoplasmic localization of NORPEG(RAI14)protein[J].Biochem Biophys Res Commun,2006,345(4):1333-1341.
9 Ding CL,Qian CL,Qi ZT,et al.Identification of retinoid acid induced 16 as a novel androgen receptor target in prostate cancer cells[J].Mol Cell Endocrinol,2020,506:110745.
10 Ge J,Liu SL,Zheng JX,et al.RNA demethylase ALKBH5 suppresses tumorigenesis via inhibiting proliferation and invasion and promoting CD8(+)T cell infiltration in colorectal cancer[J].Transl Oncol,2023,34:101683.
11 Qu Y,Zhang L,Wang J,et al.Yes-associated protein(YAP)predicts poor prognosis and regulates progression of esophageal squamous cell cancer through epithelial-mesenchymal transition[J].Exp Ther Med,2019,18(4):2993-3001.
12 Jedrzkiewicz J,Sirohi D,Uvejzovic N,et al.RAI1 alternate probe identifies additional gastroesophageal adenocarcinoma cases as amplified following equivocal HER2 fluorescence in situ hybridization testing:experience from a national reference laboratory[J].Mod Pathol,2022,35(4):549-553.
13 Yan W,Wu K,Herman JG,et al.Retinoic acid-induced 2(RAI2)is a novel tumor suppressor,and promoter region methylation of RAI2 is a poor prognostic marker in colorectal cancer[J].Clin Epigenetics,2018,10:69.
14 Zhang W,Kong L,Zhu H,et al.Retinoic acid-induced 2(RAI2)is a novel antagonist of Wnt/β-catenin signaling pathway and potential biomarker of chemosensitivity in colorectal cancer[J].Front Oncol,2022,12:805290.
15 Taheriazam A,Bayanzadeh SD,Heydari Farahani M,et al.Non-coding RNA-based therapeutics in cancer therapy:An emphasis on Wnt/β-catenin control[J].Eur J Pharmacol,2023,951:175781.
16 石琳娜,隋红.原发性肝癌免疫检查点抑制剂治疗的进展与挑战[J].实用肿瘤学杂志,2020,34(6):560-564.
17 Yu Y,Lu X,Yan Y,et al.The lncRNA KIF9-AS1 accelerates hepatocellular carcinoma growth by recruiting DNMT1 to promote RAI2 DNA methylation[J].J Oncol,2022,2022:3888798.
18 Lim LJ,Wong SYS,Huang F,et al.Roles and regulation of long noncoding RNAs in hepatocellular carcinoma[J].Cancer Res,2019,79(20):5131-5139.
19 Wong KK.DNMT1 as a therapeutic target in pancreatic cancer:mechanisms and clinical implications[J].Cell Oncol(Dordr),2020,43(5):779-792.
20 Jiang X,Xu X,Wu M,et al.GPRC5A:An Emerging biomarker in human cancer[J].Biomed Res Int,2018,2018:1823726.
21 Liang M,Huang G,Liu Z,et al.Elevated levels of hsa_circ_006100 in gastric cancer promote cell growth and metastasis via miR-195/GPRC5A signalling[J].Cell Prolif,2019,52(5):e12661.
22 Melling N,Bachmann K,Bockhorn M,et al.RAI3 is overexpressed in gastric adenocarcinoma but unrelated to prognosis[J].Int J Clin Exp Pathol,2019,12(2):606-612.
23 Xin H,Wang K,Hu G,et al.Establishment and characterization of 7 novel hepatocellular carcinoma cell lines from patient-derived tumor xenografts[J].PLoS One,2014,9(1):e85308.
24 陈偲,王颖,谢生茂,等.GPRC5A对肝癌细胞增殖、凋亡和氧化应激的影响及作用机制探讨[J].现代检验医学杂志,2021,36(6):10-16+59.
25 徐婷,程华,张维.老年胰腺癌早期诊断及微创外科治疗的研究进展[J].实用肿瘤学杂志,2023,37(3):257-261.
26 Wu Q,Ding W,Mirza A,et al.Integrative genomics revealed RAI3 is a cell growth-promoting gene and a novel P53 transcriptional target[J].J Biol Chem,2005,280(13):12935-12943.
27 Jahny E,Yang H,Liu B,et al.The G protein-coupled receptor RAI3 is an independent prognostic factor for pancreatic cancer survival and regulates proliferation via STAT3 phosphorylation[J].PLoS One,2017,12(1):e0170390.
28 Liu B,Yang H,Pilarsky C,et al.The effect of GPRC5a on the proliferation,migration ability,chemotherapy resistance,and phosphorylation of GSK-3β in pancreatic cancer[J].Int J Mol Sci,2018,19(7).
29 元建华,张曙波,李建旺,等.GPRC5A、SOCS3和STAT3在结直肠癌组织中的表达及相关性分析[J].中国癌症防治杂志,2019,11(6):518-522.
30 Wang J,Cai Y,Luo J,et al.RAI14 silencing suppresses progression of esophageal cancer via the STAT3 pathway[J].Aging(Albany NY),2020,12(18):18084-18098.
31 Zhang R,Hu M,Chen HN,et al.Phenotypic heterogeneity analysis of APC-mutant colon cancer by proteomics and phosphoproteomics identifies RAI14 as a key prognostic determinant in east Asians and Westerners[J].Mol Cell Proteomics,2023,22(5):100532.
32 Hsu YC,Chen HY,Yuan S,et al.Genome-wide analysis of three-way interplay among gene expression,cancer cell invasion and anti-cancer compound sensitivity[J].BMC Med,2013,11:106.
33 Chen C,Maimaiti A,Zhang X,et al.Knockdown of RAI14 suppresses the progression of gastric cancer[J].Onco Targets Ther,2018,11:6693-6703.
34 Xiao Y,Zhang H,Du G,et al.RAI14 Is a Prognostic biomarker and correlated with immune cell infiltrates in gastric cancer[J].Technol Cancer Res Treat,2020,19:1533033820970684.
35 Yeung SF,Zhou Y,Zou W,et al.TEC kinase stabilizes PLK4 to promote liver cancer metastasis[J].Cancer Lett,2022,524:70-81.
36 Wang W,Zhao LJ,Yang Y,et al.Retinoic acid induced 16 enhances tumorigenesis and serves as a novel tumor marker for hepatocellular carcinoma[J].Carcinogenesis,2012,33(12):2578-2585.

[1]	赵金璐, 李国东刘明. 长链非编码RNA CCAT1与消化系统恶性肿瘤关系的研究进展[J]. 实用肿瘤学杂志, 2019, 33(4): 367-370.
[2]	王鹏综述, 王征, 周志祥审校. p53与消化系统恶性肿瘤的研究进展[J]. 实用肿瘤学杂志, 2016, 30(5): 468-472.
[3]	宋福山;王雅杰;孙艳丽;任既晨. 羟基喜树碱、5-氟脲嘧啶联合应用治疗晚期消化道恶性肿瘤疗效观察[J]. 实用肿瘤学杂志, 2000, 14(02): 107-108.

维甲酸诱导蛋白在消化系统恶性肿瘤中的研究进展

Research progress on retinoic acid-induced proteins in malignant tumors of the digestive system

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 3

编辑推荐

Metrics

本文评价