Abstract: Objective To discuss on the BALB/C of lung tissue in mice after irradiation,TNF-alpha and IL-1alpha release characteristics of cytokines in the lung and liver.Methods Irradiation of male BALB/C mouse 30 was randomly assigned to a group(R)and the control group(C).R group:24 / group,C group:6 / group,6MV-X -Ray 25Gy chest irradiation;two groups of mice after exposure to 1,and 2,and 3 months were executed using immunohistochemical Methods for detection of irradiation in mouse lung and liver tissue of TNF-α and IL-1α expression levels.Results R group of TNF-α and IL-1α expressions in lung and liver levels of exposure to 1,and 2,and 3 months of significantly higher C(P＜0.01)and 2 months after the expression of the highest.Conclusion Lung tissues after exposure TNF-α and IL-1α expressions in lung and liver levels are significantly increased.Exposure 2 months in mice TNF-α and IL-1α expressions are particularly significant.