关键词: 依托咪酯, 丙泊酚, 乳腺良性肿瘤, 靶控输注

Abstract: Objective To explore the efficacy and side effect of target controlled infusion(TCI)of etomidate in benign breast tumors operation.Methods Sixty patients undergoing benign breast tumors operation were randomly divided into two groups(n=30):etomidate group(group E),etomidate were given by TCI targeting effect-site(0.3μg/mL);propofol group(group P),propofol were given by TCI targeting effect-site(3μg/mL).The two groups were all given midazolam 2~3mg,sufentanyl by TCI targeting effect-site(0.1ng/mL).The HR,ECG,SpO₂ and MAP in two groups were continuously monitored during the study.Respiratory depression,myoclonus,post operation nausea and vomiting were recorded.Results Compared with group P,group E had more stabilized hemodynamics(P＜0.05),lower respiratory depression incidence(P＜0.05)and higher sedation degree(P＜0.05).There was no significant difference in myoclonus between them,but the Group E has higner incidence than group P in post operation nausea and vomiting.Conclusion Both etomidate and propofol given by target controlled infusion can be safely used in benign breast tumors,but the etomidated group had more stabilized hemodynamics and lower respiratory depression incidence than propofol group.Besides,group E had higher incidence of postoperative nausea and vomiting.

Key words: Etomidate, Propofol, Benign breast tumors, Target controlled infusion