实用肿瘤学杂志 ›› 2015, Vol. 29 ›› Issue (6): 533-535.doi: 10.11904/j.issn.1002-3070.2015.06.011

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异基因造血干细胞移植联合供者源淋巴细胞及EBV特异性杀伤T细胞治疗种痘水疱样淋巴瘤一例报告及文献复习

徐数娜, 刘丽辉, 张永清, 胡文青   

  1. 解放军第309医院(北京 100094)
  • 收稿日期:2015-05-21 出版日期:2015-12-28 发布日期:2015-12-28
  • 通讯作者: 刘丽辉,E-mail:13621292986@163.com E-mail:13621292986@163.com
  • 作者简介:徐数娜,女,(1984-),硕士,住院医师,从事血液病学的研究

Allogeneic hematopoietic stem cell transplantation followed by donor derived lymphocyte and EBV specific cytotoxic T-lymphocyte immunotherapy for hydroa vacciniforme-like lymphoma:A case report and literature review

XU Shuna, LIU Lihui, ZHANG Yongqing, HU Wenqing   

  1. The 309th Hospital of Chinese People′s Liberation Army,Beijing 100094,China
  • Received:2015-05-21 Online:2015-12-28 Published:2015-12-28

摘要: 种痘水疱样淋巴瘤临床表现为疱疹,伴有发热、肝脾肿大、淋巴结肿大等系统症状。病理示真皮内淋巴细胞浸润,可见部分异形细胞,免疫组化示Bcl-6、Bcl-2、CD3、CD8、TIA、CD4、granzyme和EBER均阳性,而CD56、CD20均阴性。骨髓细胞TCR重排阳性。种痘水疱样淋巴瘤较罕见,临床易误诊。传统治疗效果差,异基因造血干细胞移植联合回输淋巴细胞及EBV特异性杀伤T细胞治疗种痘水疱样淋巴瘤的疗效好,可能是根治HVLL的有效手段。

关键词: 种痘水疱样淋巴瘤, 造血干细胞移植, EBV特异性杀伤T细胞

Abstract: The hydroa vacciniforme-like lymphoma is clinically manifested by rash,fever,hepatosplenomegaly and lymphadenectasis.Pathological character showed that lymphocytes infiltrated into dermis and there were some heterocysts.Immunohistochemistory showed that Bcl-6,Bcl-2,CD3,CD8,TIA,CD4,granzyme,EBER were positive,CD56,CD20 all tested negative.The rearrangement of TCR of bone marrow cell was positive.The hydroa vacciniforme-like lymphoma is uncommon clinically,and it is easy to misdiagnosed.The effect of traditional therapy is poor,while the allogeneic hematopoietic stem cell transplantation followed by lymphocyte and donor-derived EBV-specific cytotoxic T-lymphocyte immunotherapy is effective,which may offer an curable therapy for HVLL.

Key words: Hdroa vacciniforme-like lymphoma, Hematopoietic stem cell transplantation, EBV-specific cytotoxic T-lymphocyte

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