肿瘤抑素的应用及研究进展

doi:10.11904/j.issn.1002-3070.2015.06.015

实用肿瘤学杂志 ›› 2015, Vol. 29 ›› Issue (6): 549-552.doi: 10.11904/j.issn.1002-3070.2015.06.015

肿瘤抑素的应用及研究进展

于倩¹, 王技军¹, 朱江², 贺岩¹

1.哈尔滨医科大学病理教研室(哈尔滨 150081);
2.哈尔滨医科大学附属第一医院

收稿日期:2015-05-25 出版日期:2015-12-28 发布日期:2015-12-28
通讯作者: 贺岩,E-mailhe_yan419@163.com: E-mail:he_yan419@163.com:
作者简介:于倩,女,(1988-),硕士研究生,从事肿瘤抑素(19肽)在胃癌作用机制的研究
基金资助:
黑龙江省卫生厅科研课题(2010-030)

The application and research progress of Tumstatin

YU Qian¹, WANG Jijun¹, ZHU Jiang², HE Yan¹

1.Department of Pathology,Harbin Medical University,Harbin 150081,China;
2.The Fist Affiliated Hospital of Harbin Medical Uiversity

Received:2015-05-25 Online:2015-12-28 Published:2015-12-28

摘要/Abstract

摘要： 肿瘤的生长需要新生血管来为其提供充足的营养物质和氧气,因此通过抑制血管的生成能够抑制肿瘤的生长。在所有来源于Ⅳ型胶原的内源性血管生成抑制剂中,肿瘤抑素的研究最广泛。肿瘤抑素具有抑制血管内皮细胞增殖、诱导内皮细胞凋亡、直接抑制肿瘤细胞增殖,促进肿瘤细胞凋亡等多种功能。本文就肿瘤抑素的研究现状进行综述。

关键词: 肿瘤抑素, 凋亡, 增殖, 血管

Abstract: Growth of tumor need new blood vessel to meet the demand for adequate oxygen and nutrients.Inhibiting the formation of blood vessel can inhibit growth of tumor.In all of the endogenous angiogenesis inhibitors deriving from the type IV collagen.Study of tumstatin is the most widely.Tumstatin can inhibit endothelial proliferation and induce the apoptosis of endothelial cell.This article reviews the research status of the tumstatin.

Key words: Tumstatin, Apoptosis, Proliferation, Blood

中图分类号:

R730.43

于倩, 王技军, 朱江, 贺岩. 肿瘤抑素的应用及研究进展[J]. 实用肿瘤学杂志, 2015, 29(6): 549-552.

YU Qian, WANG Jijun, ZHU Jiang, HE Yan. The application and research progress of Tumstatin[J]. PRACTICAL ONCOLOGY JOURNAL, 2015, 29(6): 549-552.

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肿瘤抑素的应用及研究进展

The application and research progress of Tumstatin

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