关键词: 宫颈癌, 动态增强磁共振功能成像, 同步放化疗, 疗效, 预测

Abstract: Objective To explore the predictive value of the therapeutic effect with concurrent chemoradiation about cervical carcinoma through the quantitative analysis of 3.0T dynamic enhanced MRI(DCE-MRI).Methods Thirty cases of cervical carcinoma with concurrent chemoradiation in our hospital(Guangzhou first people′s hospital)from January 2013 to March 2015 were included in our study.All the cases had been confirmed by pathology.The mean value of DCE-MRI parameters including Ktrans,Kep,Ve was measured in all cases and the Spearman analysis was made between them and tumor regression rate.Results Before treatment tumor tissue and uterine muscle TIC curve:The tumors were given priority to type III curve,before the treatment:1 case of type I(3.33%),3 cases of type II(10%),26 cases of type III(86.67%),at the end of the treatment:5 cases of type I(16.67%),13 cases of type II(43.33%),12 cases of type III(40%);uterine muscles were given priority to type I curve,before the treatment:18 cases of type I(60%),12 cases of type II(40%),at the end of the treatment:16 cases of type I(53.33%),14 cases of type II(46.67%).Tumor regression rate after treatment had positive correlation with mean value of Ktrans,Kep and Ve for tumors before treatment(r:0.124~0.668,P＜0.01~0.031).Conclusion Tumor regression rate has positive correlation with mean value of Ktrans,Kep and Ve for tumors before treatment.DCE-MRI quantitative parameters can predict the treatment effect of cervical carcinoma,which is expected to provide a basis for the individualized treatment of cervical carcinoma.

Key words: Cervical carcinoma, DCE-MRI, Concurrent chemoradiation, Therapeutic effect, Prediction