角化棘皮瘤消退机制的研究进展

doi:10.11904/j.issn.1002-3070.2017.01.018

摘要/Abstract

摘要： 角化棘皮瘤是好发于老年人曝光部位的上皮细胞肿瘤,临床行为表现为快速生长后能自行消退,其疾病分类学位于良性和恶性之间。角化棘皮瘤的消退可能与毛囊周期、细胞凋亡及机体的免疫功能相关。本文总结了诱导角化棘皮瘤消退的生物学机制,如Wnt/维甲酸信号通路的相互作用,p53、bcl-2、bcl-xL、bak在细胞凋亡中的作用,以及几种免疫相关细胞的作用机制。可以为角化棘皮瘤治疗方式及时机的选择提供理论依据。

关键词: 角化棘皮瘤, 毛囊周期, 细胞凋亡, 免疫

Abstract: Keratoacanthoma(KA)is an epithelial neoplasm occurring in sun-exposed skin of the elderly.Two striking features of KA are its clinical behavior with spontaneous regression after rapid growth and its nosological position on the border between benignity and malignancy.The regression of KA may be associated with the hair follicle cycle,apoptosis and immune function of organism.This article summarizes physiological mechanisms such as Wnt/retinoic acid signalling cross-talk,the function of p53,bcl-2,bcl-xL and bak in apoptosis,and the mechanism of action of several immune-related cells,that drives KA regression.It can provide theoretical basis for us to select the method as well as time of the treatment in KA.

Key words: Keratoacanthoma, Hair follicles cycle, Apoptosis, Immunity

中图分类号:

R739.5

刘冰梅, 程雪, 邢荣贵综述, 杨晶审校. 角化棘皮瘤消退机制的研究进展[J]. 实用肿瘤学杂志, 2017, 31(1): 83-87.

LIU Bingmei, CHENG Xue, XING Ronggui, YANG Jing. Progress in the mechanisms of keratoacanthoma regression[J]. PRACTICAL ONCOLOGY JOURNAL, 2017, 31(1): 83-87.

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