长链非编码RNA在口腔鳞状细胞癌中的研究进展

doi:10.11904/j.issn.1002-3070.2025.03.011

实用肿瘤学杂志 ›› 2025, Vol. 39 ›› Issue (3): 251-255.doi: 10.11904/j.issn.1002-3070.2025.03.011

长链非编码RNA在口腔鳞状细胞癌中的研究进展

武旭^1,2, 德乐黑巴特尔³, 达林泰¹, 苏尼特¹ 综述, 刘军² 审校

1.呼和浩特市口腔医院(内蒙古自治区口腔医院)口腔颌面外科(呼和浩特 010000);
2.呼和浩特市第二医院放射科;
3.内蒙古医科大学附属医院口腔科

收稿日期:2025-02-20 修回日期:2025-05-06 出版日期:2025-06-28 发布日期:2025-07-02
通讯作者: 刘军,E-mail:40796099@qq.com
作者简介:武旭,女,(1992—),硕士,主治医师,从事口腔颌面肿瘤及创伤的研究。
基金资助:
内蒙古自治区自然科学基金(编号:2024QN08053);内蒙古医科大学联合项目(编号:YKD2023LH032)

Research progress of long non-coding RNA in oral squamous cell carcinoma

WU Xu^1,2, DE Leheibateer³, DA Lintai¹, SU Nite¹, LIU Jun²

1. Oral and Maxillofacial Surgery,Hohhot Stomatological Hospital(Stomatological Hospital of Inner Mongolia Autonomous Region),Hohhot 010000;
2. Department of Radiology,The hohhot Second Hospital;
3. Department of Stomatology,Affiliated Hospital of Inner Mongolia Medical University

Received:2025-02-20 Revised:2025-05-06 Online:2025-06-28 Published:2025-07-02

摘要/Abstract

摘要： 口腔癌是头颈部最常见的恶性肿瘤之一,约90%的口腔癌为鳞状细胞癌。口腔鳞状细胞癌(oral squamous cell carcinoma,OSCC)恶性程度高,预后较差,严重威胁人类健康。OSCC的发生发展较为复杂,受到多因素多水平的影响和调控,目前分子机制尚未完全阐明。长链非编码RNA(long non-coding RNA,lncRNA)能够通过在转录、翻译和翻译后水平调节基因表达和功能,从而发挥多种生物学功能。OSCC的发生发展过程中涉及lncRNA的异常表达。因此本文对lncRNA在OSCC中的功能和分子机制的相关研究进行综述,以期为后续研究提供参考。

关键词: 口腔鳞状细胞癌, 长链非编码RNA, 表观遗传, 肿瘤免疫微环境, 肿瘤耐药

Abstract: Oral cancer is one of the most common malignant tumors in the head and neck,with approximately 90% of oral cancer being squamous cell carcinoma.Oral squamous cell carcinoma(OSCC)has a high degree of malignancy and a poor prognosis,posing a serious threat human health.The occurrence and development of OSCC are relatively complex,influenced and regulated by multiple factors and levels,and the molecular mechanisms is currently not fully understood.Long non-coding RNA(lncRNA)can exert various biological functions by regulating gene expression and function at the transcriptional,translational,and post-translational levels.The occurrence and development of OSCC involve the abnormal expression of lncRNA.Therefore,this article reviews the relevant research on the function and molecular mechanisms of lncRNA in OSCC,in order to provide a reference for future studies.

Key words: Oral squamous cell carcinoma, Long non-coding RNA, Epigenetic, Tumor immune microenvironment, Tumor drug resistance

中图分类号:

R739.8

武旭, 德乐黑巴特尔, 达林泰, 苏尼特, 刘军. 长链非编码RNA在口腔鳞状细胞癌中的研究进展[J]. 实用肿瘤学杂志, 2025, 39(3): 251-255.

WU Xu, DE Leheibateer, DA Lintai, SU Nite, LIU Jun. Research progress of long non-coding RNA in oral squamous cell carcinoma[J]. Journal of Practical Oncology, 2025, 39(3): 251-255.

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长链非编码RNA在口腔鳞状细胞癌中的研究进展

Research progress of long non-coding RNA in oral squamous cell carcinoma

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