结肠癌中肿瘤相关巨噬细胞的作用及靶向治疗的研究进展

doi:10.11904/j.issn.1002-3070.2018.05.013

摘要/Abstract

摘要： 结肠癌是消化道常见的恶性肿瘤,结肠癌的治疗和预后与多种因素有关。巨噬细胞是组织稳态和肿瘤微环境的关键调节剂,肿瘤相关巨噬细胞(TAM)与肿瘤发展、预后不良密切相关。TAM在结肠癌的发生、转移、耐药中起到了推动作用。临床上通过加强抗肿瘤免疫应答提高靶向治疗疗效,对重塑肿瘤微环境、提高肿瘤的治疗效果具有重要意义。故本文对结肠癌中肿瘤相关巨噬细胞的作用及靶向治疗情况进行具体的综述。

关键词: 结肠癌, 肿瘤相关巨噬细胞, 靶向治疗, 肿瘤微环境

Abstract: Colon cancer is a common malignant tumor of digestive tract.The treatment and prognosis are related to many factors.Macrophage is a key regulator of tissue homeostasis and tumor microenvironment.Tumor-associated macrophage(TAM)is closely related to tumor development and poor prognosis.TAM has played a catalytic role in the occurrence,metastasis and drug resistance of colon cancer.Clinically,enhancing the therapeutic effect by strengthening the anti-tumor immune response is of great significance for remodeling the TAM and improving the therapeutic effect of tumor.

Key words: Colon cancer, Tumor-associated macrophage, Target therapy, Tumor microenvironment

中图分类号:

R735.35

李悦, 徐可, 韩增祥, 孙敏, 樊国华综述, 张勇审校. 结肠癌中肿瘤相关巨噬细胞的作用及靶向治疗的研究进展[J]. 实用肿瘤学杂志, 2018, 32(5): 450-454.

LI Yue, XU Ke, HAN Zengxiang, SUN Min, FAN Guohua, ZHANG Yong. Advances in the role of tumor-associated macrophage in colon cancer and targeted therapy[J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(5): 450-454.

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