脂质组学在结直肠癌研究中的应用

doi:10.11904/j.issn.1002-3070.2019.02.015

摘要/Abstract

摘要： 结直肠癌是我国目前常见的恶性肿瘤之一,对健康造成了严重威胁,其发病率和死亡率呈逐年上升的趋势。临床应用的早期诊断标志物和疾病活动进展指标存在缺陷。脂质组学通过比较体内脂质代谢物变化特征差异,帮助分析结直肠癌病因、病变进展及辅助临床诊断,为结直肠癌研究提供新方法和平台,本综述对脂质组学在结直肠癌研究中的应用进行论述。

关键词: 结直肠癌, 脂质组学, 代谢, 临床诊断

Abstract: Colorectal cancer is one of the most common malignant tumors in China.It poses a serious threat to health and its morbidity and mortality are increasing year by year.There are defects in early diagnostic markers and disease activity progression indicators for clinical applications.Lipidomics helps to analyze the etiology,pathological progression and clinical diagnosis of colorectal cancer by comparing differences in lipid metabolites in vivo,providing a new method and platform for research of colorectal cancer.This review is aimed at the application of lipidomics in colorectal cancer.

Key words: Colorectal cancer, Lipidomics, Metabolism, Clinical diagnosis

中图分类号:

R735.3⁺4

佟广海, 田洋, 吴华星. 脂质组学在结直肠癌研究中的应用[J]. 实用肿瘤学杂志, 2019, 33(2): 179-192.

TONG Guanghai, TIAN Yang, WU Huaxing. Application of lipidomics in colorectal cancer[J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(2): 179-192.

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