Semaphorin 3F在肿瘤中的研究进展

doi:10.11904/j.issn.1002-3070.2020.01.017

摘要/Abstract

摘要： Semaphorin是一种分泌型或跨膜型蛋白,广泛表达于各器官与组织,作为轴突导向分子在神经系统的发育中发挥作用。越来越多的研究表明Semaphorin还在免疫系统、心血管系统及肿瘤进展方面有着重要影响。Semaphorin 3F是Semaphorin家族中的成员之一,在多种肿瘤中表达缺失。Semaphorin 3F通过与其受体结合激活相关信号通路,参与了调控肿瘤细胞的增殖、分化及转移等过程,其表达水平与肿瘤的发生、发展和预后密切相关。本文就Semaphorin 3F在肿瘤中的研究进展进行综述。

关键词: Semaphorin 3F, 肿瘤, 靶向治疗

Abstract: Semaphorin is a secreted or transmembrane protein,which is widely expressed in various organs and tissues,and acts as axonal targeting molecule in the development of the nervous system.More and more studies have shown that Semaphorin also has an important impact on the immune system,cardiovascular system and tumor progression.Semaphorin 3F is a members of the semaphorin family and is expressed in a variety of tumors.Semaphorin 3F is involved in the regulation of tumor cell proliferation,differentiation and metastasis by binding to its receptor and activating its related signaling pathways.Its expression level is closely related to tumor occurrence,development and prognosis.This article reviews the research progress of semaphorin 3F in tumors.

Key words: Semaphorin 3F, Tumor, Targeted therapy

中图分类号:

R730

左志博, 郭志琴, 王振, 杨宏杰, 邬万新. Semaphorin 3F在肿瘤中的研究进展[J]. 实用肿瘤学杂志, 2020, 34(1): 88-92.

ZUO Zhibo, GUO Zhiqin, WANG Zhen, YANG Hongjie, WU Wanxin. Research progress of Semaphorin 3F in tumors[J]. Journal of Practical Oncology, 2020, 34(1): 88-92.

参考文献

1 Hu ZQ,Zhou SL,Zhou ZJ,et al.Overexpression of semaphorin 3A promotes tumor progression and predicts poor prognosis in hepatocellular carcinoma after curative resection[J].Oncotarget,2016,7(32):51733-51746.
2 Reuer T,Schneider AC,Cakir B,et al.Semaphorin 3F modulates corneal lymphangiogenesis and promotes corneal graft survival[J].Invest Ophthalmol Vis Sci,2018,59(12):5277-5284.
3 Cole-Healy Z,Vergani P,Hunter K,et al.The relationship between semaphorin 3c and microvessel density in the progression of breast and oral neoplasia[J].Exp Mol Pathol,2015,99(1):19-24.
4 Wong HK,Shimizu A,Kirkpatrick ND,et al.Merlin/NF2 regulates angiogenesis in schwannomas through a Rac1/semaphorin 3f-dependent mechanism[J].Neoplasia,2012,14(2):84-94.
5 Nakayama H,Bruneau S,Kochupurakkal N,et al.Regulation of mTOR signaling by semaphorin 3f-neuropilin 2 interactions in vitro and in vivo[J].Sci Rep,2015,9(5):11789.
6 Procaccia V,Nakayama H,Shimizu A,et al.Gleevec/imatinib,an ABL2 kinase inhibitor,protects tumor and endothelial cells from semaphorin-induced cytoskeleton collapse and loss of cell motility[J].Biochem Biophys Res Commun,2014,448(2):134-138.
7 Nasarre P,Gemmill RM,Drabkin HA.The emerging role of class-3 semaphorins and their neuropilin receptors in oncology[J].Onco Targets Ther,2014,7:1663-1687.
8 Zheng C,Zhou Q,Wu F,et al.Semaphorin 3f down-regulates the expression of integrin alpha(v)beta3 and sensitizes multicellular tumor spheroids to chemotherapy via the neuropilin-2 receptor in vitro[J].Chemotherapy,2009,55(5):344-352.
9 Sijaona A,Luukko K,Kvinnsland IH,et al.Expression patterns of sema3f,plexina4,-a3,neuropilin1 and-2 in the postnatal mouse molar suggest roles in tooth innervation and organogenesis[J].Acta Odontol Scand,2012,70(2):140-148.
10 Hei Yuan HS,Katyal S,Anderson JE.A mechanism for semaphorin-induced apoptosis:DNA damage of endothelial and myogenic cells in primary cultures from skeletal muscle[J].Oncotarget,2018,9(32):22618-22630.
11 Uchida Y,James JM,Suto F,et al.Class 3 semaphorins negatively regulate dermal lymphatic network formation[J].Biol Open,2015,4(9):1194-1205.
12 Parker MW,Hellman LM,Xu P,et al.Furin processing of semaphorin 3f determines its anti-angiogenic activity by regulating direct binding and competition for neuropilin[J].Biochemistry,2010,49(19):4068-4075.
13 Coma S,Amin DN,Shimizu A,et al.Id2 promotes tumor cell migration and invasion through transcriptional repression of semaphorin 3f[J].Cancer Res,2010,70(9):3823-3832.
14 贺伟,母齐鸣,王刚,等.TACC3和p53蛋白在原发性肝癌组织中的表达及其临床意义[J].实用肿瘤学杂志,2018,32(5):420-425.
15 Nakayama H,Kusumoto C,Nakahara M,et al.Semaphorin 3f and netrin-1:the novel function as a regulator of tumor microenvironment[J].Front Physiol,2018,9:1662.
16 Wu F,Zhou Q,Yang J,et al.Endogenous axon guiding chemorepulsant semaphorin-3f inhibits the growth and metastasis of colorectal carcinoma[J].Clin Cancer Res,2011,17(9):2702-2711.
17 王勇,宋林繁,杨光,等.直肠癌患者肿瘤抑制因子 SEMA3F、CYLD与 miR-454 表达水平及其相关性[J].中国现代普通外科进展,2018,21(2):106-109.
18 Gao X,Tang C,Shi W,et al.Semaphorin-3f functions as a tumor suppressor in colorectal cancer due to regulation by DNA methylation[J].Int J Clin Exp Pathol,2015,8(10):12766-12774.
19 Rao J,Zhou ZH,Yang J,et al.Semaphorin-3f suppresses the stemness of colorectal cancer cells by inactivating Rac1[J].Cancer Lett,2015,358(1):76-84.
20 Zhou ZH,Rao J,Yang J,et al.SEMA3F prevents metastasis of colorectal cancer by PI3K-AKT-dependent down-regulation of the ASCL2-CXCR4 axis[J].J Pathol,2015,236(4):467-478.
21 Fan M,Yang L,Li F,et al.Axon guidance repulsant SEMA3F increases chemosensitivity to oxaliplatin and inhibits epithelial-mesenchymal transition of colorectal cancer cells[J].Transl Cancer Res,2017,6(1):206-217.
22 罗来邦,徐志丹,丁利民,等.肝细胞癌组织中信号素 3F 蛋白表达变化及其与患者预后的关系[J].山东医药,2014,54(10):21-24.
23 Bollard J,Massoma P,Vercherat C,et al.The axon guidance molecule semaphorin 3f is a negative regulator of tumor progression and proliferation in ileal neuroendocrine tumors[J].Oncotarget,2015,6(34):36731-36745.
24 Joseph D,Ho SM,Syed V.Hormonal regulation and distinct functions of semaphorin-3B and semaphorin-3F in ovarian cancer[J].Mol Cancer Ther,2010,9(2):499-509.
25 Drenberg CD,Livingston S,Chen R,et al.Expression of semaphorin 3f and its receptors in epithelial ovarian cancer,fallopian tubes,and secondary müllerian tissues[J].Obstet Gynecol Int,2009,2009:730739.
26 裴雪阳,徐云钊,谭细娟,等.卵巢癌组织SEMA3F表达及甲基化初步研究[J].中华肿瘤防治杂志,2014,21(20):1611-1616.
27 Joseph D,Ho SM,Syed V.Hormonal regulation and distinct functions of semaphorin-3b and semaphorin-3f in ovarian cancer[J].Mol Cancer Ther,2010,9(2):499-509.
28 Nguyen H,Ivanova VS,Kavandi L,et al.Progesterone and 1,25-dihydroxyvitamin D₃ inhibit endometrial cancer cell growth by upregulating semaphorin 3b and semaphorin 3f[J].Mol Cancer Res,2011,9(11):1479-1492.
29 Liu Y,Li RH,Yin K,et al.The crucial role of SEMA3F in suppressing the progression of oral squamous cell carcinoma[J].Cell Mol Biol Lett,2017,22-32.
30 Doci CL,Mikelis CM,Lionakis MS,et al.Genetic identification of SEMA3F as an antilymphangiogenic metastasis suppressor gene in head and neck squamous carcinoma[J].Cancer Res,2015,75(14):2937-2948.
31 Zhang B,Gao Z,Sun M,et al.Prognostic significance of VEGF-C,semaphorin 3f,and neuropilin-2 expression in oral squamous cell carcinomas and their relationship with lymphangiogenesis[J].J Surg Oncol,2015,111(4):382-388.
32 Ni Q,Sun J,Ma C,et al.The neuropilins and their ligands in hematogenous metastasis of salivary adenoid cystic carcinoma-an immunohistochemical study[J].J Oral Maxillofac Surg,2018,76(3):569-579.
33 Clarhaut J,Gemmill RM,Potiron VA,et al.ZEB-1,a repressor of the semaphorin 3f tumor suppressor gene in lung cancer cells[J].Neoplasia,2009,11(2):157-166.
34 Nasarre P,Gemmill RM,Potiron VA,et al.Neuropilin-2 is upregulated in lung cancer cells during TGF-β1-induced epithelial-mesenchymal transition[J].Cancer Res,2013,73(23):7111-7121.
35 Staton CA,Shaw LA,Valluru M,et al.Expression of class 3 semaphorins and their receptors in human breast neoplasia[J].Histopathology,2011,59(2):274-282.
36 Xiong G,Wang C,Evers BM,et al.RORα suppresses breast tumor invasion by inducing SEMA3F expression[J].Cancer Res,2012,72(7):1728-1739.
37 Xie W,Su W,Zhang L,et al.SSeCKS/AKAP12 induces repulsion between human prostate cancer and microvessel endothelial cells through the activation of semaphorin 3f[J].Biochem Biophys Res Commun,2017,490(4):1394-1398.
38 Beuten J,Garcia D,Brand TC,et al.Semaphorin 3b and 3f single nucleotide polymorphisms are associated with prostate cancer risk and poor prognosis[J].J Urol,2009,182(4):1614-1620.
39 Nakayama H,Huang L,Kelly RP,et al.Infantile hemangioma-derived stem cells and endothelial cells are inhibited by class 3 semaphorins[J].Biochem Biophys Res Commun,2015,464(1):126-132.
40 Jung SH,Yim SH,Hu HJ,et al.Copy number alterations and expression profiles of candidate genes in a pulmonary inflammatory myofibroblastic tumor[J].Lung Cancer,2010,70(2):152-157.
41 鲁艳杰,张淑玲,许倩,等.Semaphorin家族及其受体对肿瘤血管生成影响的研究进展[J].解放军医学院学报,2015,36(10):1056-1060.
42 Mendes-da-Cruz DA,Brignier AC,Asnafi V,et al.Semaphorin 3f and neuropilin-2 control the migration of human T-cell precursors[J].PLoS One,2014,9(7):e103405.
43 Liu MH,Fu WJ,Cui YH,et al.Downregulation of Semaphorin-3f is associated with poor prognostic significance in osteosarcoma patients[J].Am J Cancer Res,2016,6(10):2252-2262.
44 Yoshikawa Y,Sato A,Tsujimura T,et al.Frequent deletion of 3p21.1 region carrying semaphorin 3G and aberrant expression of the genes participating in semaphorin signaling in the epithelioid type of malignant mesothelioma cells[J].Int J Oncol,2011,39(6):1365-1374.

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