关键词: 胆囊癌, 发病率, 死亡率, 肿瘤登记, 甘肃

Abstract: Objective The aim of this study was to analyze the epidemiological characteristics of gallbladder carcinoma incidence and mortality in cancer registration areas of Gansu province from 2009 to 2015,so as to provide evidence for enacting prevention and treatment strategies of gallbladder carcinoma.Methods According to the auditing method of National Cancer Registration Center,the data reported by 11 cancer registries in Gansu province were collected as sample data to describe the incidence and mortality of gallbladder carcinoma in Gansu province.The incidence and mortality,age-standardized incidence/mortality rate by Chinese standard population(ASR China),age-standardized incidence/mortality rate by World standard population(ASR World)and cumulative rate(0~74 years old)were calculated.The annual percentage change(APC)was calculated using Joinpoint Regression Program 4.7.0.0 software to estimate the variation trend.Results From 2009 to 2015,there were 1 782 new cases of gallbladder carcinoma in Gansu cancer registration areas.The crude incidence rate of gallbladder carcinoma was 4.70/100 000(3.91/100 000 in male,5.54/100 000 in female),the ASR China was 4.50/100 000,and the ASR World was 5.34/100 000;There were 1 123 deaths,the crude mortality rate of gallbladder carcinoma was 2.96/100 000(2.38/100 000 in male,3.59/100 000 in female),the ASR China was 2.68/100 000,and the ASR World was 3.07/100 000.The incidence and mortality by Chinese standard population(ASR China)in urban areas(4.93/100 000,2.94/100 000)were higher than those in urban areas(1.93/100 000,1.66/100 000).The incidence and mortality of gallbladder cancer increased with age,and reached the peak in 85+ age group,showing the characteristics of urban higher than rural,female higher than male.The incidence of gallbladder cancer by ASR China in Gansu province showed a decreasing trend from 2009 to 2015(APC=-10.9%,t=-3.0,P＜0.05),and the time change trend of mortality by ASR China was not obvious(APC=-10.6%,t=-0.8,P=0.4).Conclusion Gallbladder carcinoma has become one of the common malignant tumors in Gansu province,among which the urban elderly women are the key population for the prevention and treatment of gallbladder cancer in Gansu province,it should be targeted to carry out early screening,early diagnosis and early treatment,improve the early detection rate of gallbladder cancer,reduce the incidence,mortality and disease burden of gallbladder cancer.

Key words: Gallbladder carcinoma, Incidence, Mortality, Cancer registration, Gansu