eccDNA在癌症中的研究进展

doi:10.11904/j.issn.1002-3070.2022.03.011

实用肿瘤学杂志 ›› 2022, Vol. 36 ›› Issue (3): 255-258.doi: 10.11904/j.issn.1002-3070.2022.03.011

eccDNA在癌症中的研究进展

于承平, 崔永康综述, 李林强审校

哈尔滨医科大学附属第一医院肝脏微创外科(哈尔滨 150001)

收稿日期:2021-04-16 修回日期:2021-10-27 出版日期:2022-06-28 发布日期:2022-06-28
通讯作者: 李林强,E-mail:lilq1982@126.com
作者简介:于承平,男,(1996-),硕士研究生,从事消化道肿瘤方面的研究。
基金资助:
黑龙江省博士后启动项目(编号:LBH-Q19158),哈尔滨医科大学创新科学研究资助项目(编号:31041190009)

Research progress of eccDNA in cancer

YU Chengping, CUI Yongkang, LI Linqiang

Department of Minimally Invasive Surgery of Liver,The First Affiliated Hospital of Harbin Medical University,Harbin 150001,China

Received:2021-04-16 Revised:2021-10-27 Online:2022-06-28 Published:2022-06-28

摘要/Abstract

摘要： 真核生物细胞DNA主要存在染色体上,但事实上染色体外同样存在一种特殊的环形DNA,即染色体外环状DNA(extrachromosomal circular DNA,eccDNA)。目前已经发现多种类型的eccDNA,包括小多分散DNA(small polydispersed DNA,spcDNA)、端粒环、染色体外rDNA环和微DNA(microDNA,miDNA)等。eccDNA从基因组中分离或者脱落,与染色体DNA并存,游离于染色体基因组之外,以某种特殊的方式参与机体病理或生理过程。本文针对eccDNA的分类、形成机制、在癌症中的表达和作用进行综述。

关键词: 染色体外环状DNA, 癌症, 耐药

Abstract: The DNA of eukaryotic cells mainly exists on the chromosomes,but in fact there is also DNA outside chromosomes,which is a special kind of circular DNA(extrachromosomal circular DNA,eccDNA).Several types of eccDNA have been discovered,including small polydispersed DNA(spcDNA),telomere loops,extrasomal rDNA loops and microDNA(miDNA),etc.eccDNA is separated or detached from the genome,coexists with the chromosomal DNA,and participates in pathological or physiological processes of the body in a special way.This paper summarizes the classification,formation mechanism,expression and role formation of eccDNA in cancer.

Key words: extrachromosomal circular DNA, Cancer, Drug resistance

中图分类号:

R730.2

于承平, 崔永康, 李林强. eccDNA在癌症中的研究进展[J]. 实用肿瘤学杂志, 2022, 36(3): 255-258.

YU Chengping, CUI Yongkang, LI Linqiang. Research progress of eccDNA in cancer[J]. Journal of Practical Oncology, 2022, 36(3): 255-258.

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链接本文: http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/10.11904/j.issn.1002-3070.2022.03.011

http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/Y2022/V36/I3/255

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eccDNA在癌症中的研究进展

Research progress of eccDNA in cancer

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